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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Correlation Between Clinical and Pathological Factors of Gastric Cancer ‐ A Retrosoective Study in A Tertiary Care Hospital

Kummara Gnana Venkata Sai Mounika, A. Abhiram, Channanna Chidamber Rao and Deepanraj
Page: 895-899 | Received 12 Oct 2024, Published online: 31 Dec 2024

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https://doi.org/makrjms.2024.12.895.899

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Abstract

Gastric cancer is a complex and heterogeneous disease, ranking as the fifth most prevalent cancer and the third leading cause of cancer‐related mortality globally in 2018. A deeper understanding of the proliferative and apoptotic changes in gastric cancer, along with the identification of novel biomarkers for cancer detection and therapeutic targets, could advance diagnosis, treatment, and prevention efforts. Previous research indicates that 0.7 million individuals succumb to gastric cancer annually, with approximately 70% of cases exhibiting a significantly higher mortality rate compared to other malignancies, such as liver and breast cancers. This retrospective study was conducted from July 2023 to November 2024 at a tertiary care center in the PES Institute of Medical Sciences and Research in Andhra Pradesh. The inclusion criteria comprised patients aged = 18 years, histologically confirmed cases of gastric adenocarcinoma, patients who underwent gastrectomy (partial/total) or biopsy for unresectable tumors, and patients who provided informed consent. Of the 80 patients, 50 (62.5%) were male and 30 (37.5%) were female; 50 (62.5%) underwent distal gastrectomy, 5 (6.25%) underwent proximal gastrectomy through the abdomen, 15 (18.75%) had proximal gastrectomy via the thorax, and 10 (12.5%) underwent complete gastrectomy. Distal and complete gastrectomy demonstrated greater lymph node clearances than the other surgical techniques. Postoperative complications occurred in eight patients (10%), including gastric retention (20%), anastomotic leakage (10.5%), incision infection (9.25%), wound disruption (5.25%), and thoracic cavity effusion (5.25%). Complications were more prevalent in individuals undergoing proximal gastrectomy through the abdomen (30%). Overall, the mortality rate was 1.25% (1/80). The diameter of the neoplasm was associated with the depth of infiltration and the rate of lymphatic metastasis, although hemoglobin level was not. Twelve (15%) of 80 patients had early gastric cancer (EGC) with lymph node metastases. This retrospective investigation found that the clinicopathological characteristics of gastric cancer varied according to sex, location, and tumor diameter.

How to cite this article:

Kummara Gnana Venkata Sai Mounika, A. Abhiram, Channanna Chidamber Rao and Deepanraj . Correlation Between Clinical and Pathological Factors of Gastric Cancer ‐ A Retrosoective Study in A Tertiary Care Hospital.
DOI: https://doi.org/10.36478/makrjms.2024.12.895.899
URL: https://www.makhillpublications.co/view-article/1815-9346/makrjms.2024.12.895.899