Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Vesiculobullous skin lesions represent a heterogeneous group of disorders characterized by intraepidermal or subepidermal blister formation due to varied etiologies including autoimmune, infectious, genetic, or drug‐induced causes. Accurate diagnosis requires correlation between clinical presentation and histopathological features, often supplemented by immunofluorescence studies. To study the clinical and histopathological correlation of vesiculobullous skin lesions in patients presenting to a tertiary care institution. To evaluate the clinicopathological correlation of vesiculobullous skin lesions in patients presenting to a tertiary care hospital. The most common age group affected was 41–60 years, with a slight female predominance. Autoimmune blistering disorders constituted the majority of cases (62.7%), with pemphigus vulgaris being the most frequent (34.7%), followed by bullous pemphigoid (18.7%). Infectious and hereditary blistering diseases accounted for 21.3% and 10.7% respectively. Clinicopathological correlation was established in 89.3% of cases. Histopathology revealed intraepidermal blisters in pemphigus group and subepidermal blisters in pemphigoid group. Direct immunofluorescence helped confirm diagnosis in selected cases. A multidisciplinary approach combining clinical features, histopathology, and immunofluorescence is essential for accurate diagnosis and classification of vesiculobullous lesions. High clinicopathological correlation highlights the utility of skin biopsy in guiding targeted therapy and improving patient outcomes.
How to cite this article:
G. Rajan, S. Roselin and Lilarani Vijayaragavan. Clinicopathological Correlation of Vesiculobullous Lesions of Skin: An Institutional Study.
DOI: https://doi.org/10.36478/makrjms.2024.12.856.859
URL: https://www.makhillpublications.co/view-article/1815-9346/makrjms.2024.12.856.859