Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
Laryngopharyngeal Reflux (LPR), an extra-esophageal manifestation of GERD, presents with nonspecific symptoms and often lacks classical GERD features. Proton Pump Inhibitors (PPIs) are widely used in LPR treatment, though their effectiveness remains debated. This study evaluates the clinical efficacy of PPI therapy in LPR management in a South Indian population. A prospective quasi-experimental study was conducted over six months in a tertiary center in South India. Adults aged 18-60 years with clinical symptoms of LPR (RSI $13 and RFS >7) were prescribed pantoprazole 40 mg twice daily for 8 weeks. RSI and RFS scores were assessed pre- and post-treatment. Lifestyle modifications were also documented. Data were analyzed using paired t-tests and logistic regression. Among 100 participants (mean age 38.6±10.5 years, 56% female), the mean RSI score improved from 20.8 to 10.2 and RFS from 9.7 to 5.2 (p<0.001). Complete response (RSI <13 and RFS <7) was seen in 58%, partial in 28% and no response in 14%. Lifestyle modifications significantly improved treatment outcomes (p<0.01). Logistic regression identified symptom severity and lifestyle adherence as independent predictors of treatment response. PPI therapy significantly improves symptoms and laryngoscopic findings in LPR patients, particularly when combined with lifestyle changes. A tailored, multifactorial approach is essential for optimal management of LPR in Indian settings.
How to cite this article:
B. Aurobindo, G. Sankara Narayanan and H.S. Sabari Nath. Analysis of the Role of Proton Pump Inhibitors in Laryngopharyngeal Reflux Disease: A Clinical Evaluation in a South Indian Population.
DOI: https://doi.org/10.36478/makrjms.2024.12.815.819
URL: https://www.makhillpublications.co/view-article/1815-9346/makrjms.2024.12.815.819