Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Preterm labor is a significant cause of neonatal morbidity and mortality and the management of women at risk is crucial in improving outcomes. Progesterone has been identified as a potential therapeutic agent in preventing preterm labor due to its role in maintaining uterine quiescence. This study aims to evaluate the efficacy of progesterone in preventing preterm labor among women at risk in a tertiary care center. A prospective cohort study was conducted at a tertiary care centre in Tami Nadu, including 150 pregnant women identified as high risk for preterm labor between Aug 2022 and September 2023. Participants were administered either intravaginal progesterone (200 mg daily) or no treatment, based on patient consent and clinical indication. Inclusion criteria were singleton pregnancies between 24 and 34 weeks of gestation, with risk factors such as a history of preterm birth, cervical length #25 mm, or symptoms of preterm labor. Primary outcomes measured were gestational age at delivery and incidence of preterm birth (<37 weeks). Secondary outcomes included neonatal morbidity and mortality rates. The progesterone group (n = 75) had a significantly lower incidence of preterm birth (15%) compared to the control group (30%%) (p<0.05). The mean gestational age at delivery was higher in the progesterone group (36.2±2.1 weeks) compared to the control group (34.5±3.0 weeks). Additionally, neonatal outcomes such as respiratory distress syndrome and NICU admissions were lower in the progesterone group. Progesterone administration significantly reduces the risk of preterm birth and improves neonatal outcomes in women at risk of threatened preterm labor. This supports the use of progesterone as a prophylactic treatment in high-risk pregnancies.
How to cite this article:
Nirmala , N.V. Priyanka and Binusha J. Ashok. Role of Progesterone in Antenatal Women at Risk of Threatened Preterm Labour in a Tertiary Care Centre.
DOI: https://doi.org/10.36478/makrjms.2024.11.857.862
URL: https://www.makhillpublications.co/view-article/1815-9346/makrjms.2024.11.857.862