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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Risk Factors and Predictive Indicators of Secondary Vertebral Compression Fracture Following Percutaneous Vertebral Augmentation: Insights from a Retrospective Analysis

K.C. Mathew, T. Uvarajan and S. Kavin Raja
Page: 659-663 | Received 25 Sep 2024, Published online: 10 Nov 2024

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https://doi.org/10.36478/makrjms.2024.11.659.663

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Abstract

This study aimed to identify the incidence and risk factors associated with secondary vertebral compression fractures (SVCFs) following percutaneous vertebral augmentation (PVA) in patients with osteoporotic vertebral compression fractures (OVCFs). A retrospective analysis of 64 patients who underwent PVA from January 2020 to December 2023 was performed. Patients were divided into the Non‐SVCF group (n=48) and the SVCF group (n=16) based on postoperative outcomes. Data collected included demographic characteristics, clinical factors, imaging findings, and procedural details. Statistical analyses, including univariate and multivariate logistic regression, were conducted to identify significant risk factors. Receiver operating characteristic (ROC) curve analysis evaluated the predictive efficacy of these factors. The incidence of SVCFs was 25% (16/64). Patients in the SVCF group were older (75.2±7.8 years) than those in the Non‐SVCF group (70.5±8.1 years., p=0.025). Fat infiltration rates (FIR) of the psoas major (8.5±1.7% vs. 4.7±1.2%., p=0.003) and erector spinae muscles (55.6±6.1% vs. 39.2±4.5%., p=0.002) were significantly higher in the SVCF group. Cement leakage occurred more frequently in the SVCF group (62.5% vs. 25.0%., p=0.001). Multivariate logistic regression identified FIR of the psoas major (OR: 2.35, 95% CI: 1.50‐3.68., p=0.005), FIR of the erector spinae (OR: 3.12, 95% CI: 2.01‐ 4.84., p=0.001) and cement leakage (OR: 9.04, 95% CI: 3.65‐22.38., p<0.001) as independent predictors. The combined predictive model demonstrated excellent efficacy with an AUC of 0.895. Advanced age, increased fat infiltration of paraspinal muscles, and cement leakage were significant risk factors for SVCFs following PVA. Preventive strategies focusing on muscle health, precise surgical techniques and careful postoperative monitoring are essential to reduce the risk of SVCFs. These findings offer a robust foundation for optimizing patient care and improving outcomes in OVCF management.

How to cite this article:

K.C. Mathew, T. Uvarajan and S. Kavin Raja. Risk Factors and Predictive Indicators of Secondary Vertebral Compression Fracture Following Percutaneous Vertebral Augmentation: Insights from a Retrospective Analysis.
DOI: https://doi.org/10.36478/makrjms.2024.11.659.663
URL: https://www.makhillpublications.co/view-article/1815-9346/makrjms.2024.11.659.663