Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Duodenal biopsies are a cornerstone in the diagnostic evaluation of malabsorption syndromes, providing invaluable histopathological insights that cannot be achieved through clinical assessment and laboratory tests alone. In present study, we aimed to study role of duodenal biopsy in malabsorption syndrome at a tertiary hospital. Present study was single-center, prospective and retrospective, observational study, conducted all endoscopic duodenal biopsy samples from patients presenting with malabsorption syndrome, underwent histopathology and Immunohistochemistry (IHC) evaluation. Among 101 cases, middle-aged group (18-50 years) constitutes the largest segment at 63.3%. The male-to- female ratio was 1.46:1, with a male predominance. The largest number of cases by H&E staining were in grade 0 (87%) followed by Grade 3a (6.9%) and grade 2, 3b and 3c. However, after IHC with CD3 and re- enumeration, the number of cases of grade 0 drastically fell to 23.7% followed by 21.7% grade 3a, grade 1, grade2, grade3b and grade 3c in decreasing order. Final distribution of M-O grades in the series after IHC was 23.7% (24/101) in grade 0, 21.7% in grade 3a followed by 20.7% (21/101) grade 1, 16.8% grade 2 (17/101), 10.8% (11/101) in 3b and 5.9(6/101) in grade 3c. By employing a detailed evaluation using the Marsh-Oberhuber classification, alongside advanced immunohistochemistry (IHC) techniques, we were able to describe various histological grades associated with malabsorption syndromes, particularly celiac disease.
How to cite this article:
M. Soorya, N.S. Mani and Reena Bharadwaj. A Cross-Sectional Analytical Study of Duodenal Biopsy in Malabsorption Syndrome.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.9.18.598.603
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.9.18.598.603