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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Study of Clinical Features and Outcome in Patients of Primary CNS Lymphoma at a Regional Cancer Hospital

Tushar R. Mule, Pooja S. Mote, Prabhakar S. Jirwankarm and Asha A. Anand
Page: 6-12 | Received 24 Feb 2024, Published online: 03 Apr 2024

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https://doi.org/10.36478/10.59218/makrjms.2024.6.6.12

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Abstract

Primary central nervous system lymphoma (PCNSL) is an aggressive lymphoma involving only the CNS (brain parenchyma, spinal cord, eyes, cranial nerves and meninges). Present study was aimed to study clinical features and outcome in patients of primary CNS lymphoma, at a regional cancer hospital. Present study was single‐center, prospective, observational study, conducted in patients with pathologically proven Primary central nervous system lymphoma (PCNSL). In present study, out of the 41 patients of PCNS Lymphoma the number of male and females patients were 26 (63.4%) and 15 (36.5%) respectively. Maximum patients were within age group of 51‐60 years (29.2 %). Maximum patient in our study were in ECOG PS 3 group i.e. 14 (34.14%) followed by ECOG PS 2 group i.e. 12 (29.26%). Majority patients presented with focal neurological deficit (hemi paresis, cranial nerve palsies, aphasia, cerebellar signs) (58.53%), followed by neuro psychotic symptoms (apathy, depression, confusion or cognitive decline) (53.65%) and features of raised intra cranial tension (headache, vomiting or impaired consciousness) (51.21%). 22 (53.65%) patients with PCNS lymphoma had single brain lesion while 19 (46.34%) patient had multiple brain lesion. Majority patients fall in IELSG score of 3 (29.26%) followed by score 2 (26.82%). Majority patients underwent gross total excision of lesion (51.21%) followed by stereotactic biopsy (24.39%), subtotal excision and open biopsy (9.75% each). Majority received combination chemotherapy plus WBART (39.02%). 37 patients who were available for survival analysis median OS was 14.8 months for maximum follow up of 21.3 months. On univariate survival analysis of possible prognostic factors for survival for the patients with PCNS Lymphoma, factors found to be significant were treatment, ECOG performance status, age and IELSG score.

How to cite this article:

Tushar R. Mule, Pooja S. Mote, Prabhakar S. Jirwankarm and Asha A. Anand. Study of Clinical Features and Outcome in Patients of Primary CNS Lymphoma at a Regional Cancer Hospital.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.6.6.12
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.6.6.12