Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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An Observational Study to Evaluate the Clinical Outcome in Locally Advanced Carcinoma Cervix Using HDR Brachytherapy (4# X7 Gy) in between External Beam Radiotherapy (46Gy/23#)
Umesh Dewangan, Rahul Swaroop Singh, Manjula Beck, Akhilesh Sahu, Vivek Choudhary, Pradeep Kumar Chandrakar, Rajeev Ratan Jain and Divya Fransis
Page: 47-52 | Received 20 Feb 2024, Published online: 13 Apr 2024
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Abstract
Cervical cancer is a highly curable disease when diagnosed in early stage. In India, due to lack of screening and early detection programmes, 70% to 80% of the women with cervical cancer are diagnosed with locally advanced disease where uncontrolled locoregional pelvic disease is the cause of morbidity. Thus locoregional control is of paramount importance to improve survival. to evaluate the efficacy and feasibility of using high dose rate Brachytherapy (4#x7Gy) in between external beam radiotherapy (46Gy/23#) and to shorten the overall treatment time for better patient compliance and also to observe the loco‐regional control of disease. The study was performed in the Department of Radiotherapy, Regional Cancer Institute, DR. B.R.A.M. Hospital, Raipur(C.G.) Total 50 patients of cervical cancer up to IIIB who were diagnosed as cervical cancer are taken in the study. Most of the patients (>50%) belonged to menstruating age group. Maximum patients (68%) had 3‐5 pregnancies. Histopathologically most of the patients (96%) had squamous cell carcinoma. Majority of the patients (48%) reported with stage IIIB. Majority of the patients (66%) were classified under moderately differentiated carcinoma. 37(74%) patients completed their treatment before 56 days and remaining 13(26%) patients completed their treatment after 56 days due to mechanical errors. Patients in case study received Cisplatin 40mg/m2 weekly on day 1, 8, 15, 22 and 29 at least 4‐6 hours before EBRT concurrently with HDR Brachytherapy in between External Beam Radiotherapy. Response after 1 month of completion of treatment: 1(2%) patient showed partial response and 49(98%) patients showed complete response. Response after 3 months of completion of treatment: 34(68%) patients showed complete response, 1(2%) patient showed progressive disease (para aortic node and multiple lung metastasis) and 15(30%) patients lost to follow up due to illiteracy, lack of awareness and poverty. Response after 6 months of completion of treatment: 34(68%) patients showed complete response, 1(2%) patient died due to distant para aortic and lung metastasis and 15(30%) patients lost to follow up due to illiteracy, lack of awareness and poverty.
How to cite this article:
Umesh Dewangan, Rahul Swaroop Singh, Manjula Beck, Akhilesh Sahu, Vivek Choudhary, Pradeep Kumar Chandrakar, Rajeev Ratan Jain and Divya Fransis. An Observational Study to Evaluate the Clinical Outcome in Locally Advanced Carcinoma Cervix Using HDR Brachytherapy (4# X7 Gy) in between External Beam Radiotherapy (46Gy/23#).
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.6.47.52
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.6.47.52