Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Comparative Study of Hemodynamic Effect, Recovery Pattern and Seizure Activity of Propofol and Etomidate in Electroconvulsive Therapy
Devika Dharamapal Shahu, Naina Parag Dalvi, Suchita Kosare and Anita Shetty
Page: 162-168 | Received 19 Feb 2024, Published online: 22 Apr 2024
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Abstract
During ECT, the hemodynamic effects include an elevation in systolic blood pressure, pulse pressure, pulse rate and in certain cases arrhythmias. Present study was aimed to compare hemodynamic effect, recovery pattern and seizure activity of propofol and etomidate in electroconvulsive therapy. Present study was prospective, randomized, double‐blind, comparative study, conducted in patients with age 18‐ 60 year, belonging to either sex, ASA grade I and II, undergoing ECT. By computer generated randomized schedule, patients were randomized to receive Group 1 (Etomidate 0.2 mg/kg) and Group 2 (Propofol 1 mg/kg). There were significant changes in the heart rate in group 2 from 1 minute after ECT till five minutes while there was no statistically significant difference between the mean heart rate of patients in group 1. There was significant fall in the SBP in group 2 as compared to group 1 from 1 minute after ECT till 20 minutes. (p = 0.0001). There were significant changes in the SBP in group 2 from 1 minute after ECT till 20 minutes while there was no statistically significant difference between the mean SBP of patients in group 1. There was significant fall in the DBP in group 2 as compared to group 1 from after ECT till 15 minutes. (p = 0.0001). There were significant changes in the DBP in group 2 from after ECT applying till 15 minutes while there was statistically significant difference between the mean DBP of patients in group 1 at 1 minute after ECT, five minute and 10 minutes after ECT. Nausea (3) and vomiting (4) was observed more in Group 1, which was also statistically significant. Respiratory depression and Hypotension were more compared with Group 2 patient than group1 (p‐0.001) As an inducing agent, etomidate(0.1mg/kg) has better hemodynamic stability in ECT procedure in comparison with propofol.
How to cite this article:
Devika Dharamapal Shahu, Naina Parag Dalvi, Suchita Kosare and Anita Shetty. Comparative Study of Hemodynamic Effect, Recovery Pattern and Seizure Activity of Propofol and Etomidate in Electroconvulsive Therapy.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.6.162.168
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.6.162.168