Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
Breast cancer, a heterogeneous disease, exhibits diverse molecular profiles which significantly influence treatment decisions and prognosis. Immunohistochemistry (IHC) serves as a cornerstone in identifying these molecular subtypes, providing essential data for effective clinical management. This research focuses on analyzing and categorizing breast carcinoma cases using molecular classification derived from Immunohistochemistry, aiming to understand the prevalence of different molecular types within a specific patient cohort. Employing a retrospective study design, this research included 100 cases of invasive breast carcinoma diagnosed at our center from 2013 ‐ 2016. The cases were categorized into four molecular types: Luminal Type A, Luminal Type B, Her2 Neu type and Triple negative/Basal type, utilizing Immunohistochemistry techniques. The case analysis revealed varying prevalences of molecular types among the patients: Luminal Type A (29%), Luminal Type B (13%), Her2 Neu type (32%), and Triple negative (26%). These findings underscore the heterogeneity of breast carcinoma presentations and molecular characteristics in a clinical setting. The molecular classification of breast carcinoma through Immunohistochemistry offers critical insights into the predominant types in a tertiary care setting, facilitating targeted therapeutic strategies and better patient management.
How to cite this article:
S. Abinizha, R. Narayana Vadivoo, S. Divya and Swaminathan Rajendiran. Classification of Breast Carcinoma Based on Immunohistochemistry: An Experience in a Tertiary Care Hospital.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.6.127.131
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.6.127.131