Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
184
Views
9
Downloads
Study on p53 Expression in Carcinoma Cervix and it’s Correlation with Clinical Parameters, Grading and Staging: A Cross‐Sectional Study
Shilpi Singh, Kamal Malukani, Siddharth Singh Chauhan, Purti Agrawal Saini and Piyush Kumar Mishra
Page: 620-624 | Received 03 Apr 2024, Published online: 08 May 2024
Full Text Reference XML File PDF File
Abstract
Carcinoma cervix is the fourth most common cancer in women globally and its incidence and mortality are much higher in developing countries. The persistent high risk Human papilloma virus infection is the main etiologic agent and inactivation of p53 by HPV oncoprotein E6 represents the key event in cervical carcinogenesis. To evaluate the frequency and pattern of P53 expression in carcinoma cervix and correlate with age, parity, hormonal status, histologic type, grading and clinical staging. This cross‐sectional study included a total of 100 biopsy/hysterectomy proven cases of cervical carcinoma during the two and half years study period. All relevant clinical parameters were noted and each case examined in detail for gross and microscopic findings. Immunohistochemical marker p53 was applied in all cases and its intensity and grading was assessed and correlated with clinicopathologic parameters. Data analysed by SPSS version 27 and correlation was measured by chi‐square and Fischer exact test. The mean age of cervical carcinoma patients was 52. 5 years and 74% were postmenopausal. A total of 85% cases were squamous cell carcinoma, 9% were adenocarcinoma and 3% were premalignant (SIL) cases. There was no association between P53 positivity and score with age, parity, hormonal status, Broder’s grading and FIGO clinical staging. The p53 expression was significantly associated with histologic variant as it is higher in SCC. The P53 expression was negative in two cases of LSIL whereas positive in HSIL. The p53 expression progressively increased from intra epithelial lesion to malignant lesion. This observation can be useful to differentiate SIL from invasive lesions in difficult situation. Thus it can be used as diagnostic biomarker.
How to cite this article:
Shilpi Singh, Kamal Malukani, Siddharth Singh Chauhan, Purti Agrawal Saini and Piyush Kumar Mishra. Study on p53 Expression in Carcinoma Cervix and it’s Correlation with Clinical Parameters, Grading and Staging: A Cross‐Sectional Study.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.5.620.624
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.5.620.624