Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Ocular surface squamous neoplasia (OSSN) poses significant challenges in management due to its varied presentation and potential risks associated with surgical interventions. This study explores the safety and efficacy of topical 5‐fluorouracil (5‐FU) as a sole therapy for OSSN, providing an alternative to surgical approaches. A retrospective analysis was conducted on 10 number of patients diagnosed with OSSN who underwent topical 5‐FU therapy as the primary treatment modality. Clinical data including patient demographics, lesion characteristics, treatment regimen and outcomes were collected and analyzed. Topical 5‐FU therapy resulted in complete tumor resolution in all patients after a mean of 3 monthly cycles, with no recurrences noted during the follow‐up period. Adverse effects were minimal and patient compliance was high. The therapy was well‐tolerated, with no significant complications reported. Topical 5‐FU emerges as a safe and effective treatment option for OSSN, offering comparable outcomes to surgical interventions while minimizing the risks associated with repeated surgeries. This non‐invasive approach provides patients with an alternative to surgery, particularly for those who prefer medical management or are not surgical candidates. Further studies with larger sample sizes and longer follow‐up periods are warranted to validate these findings and establish topical 5‐FU as a standard therapy for OSSN.
How to cite this article:
Kompalli Rohit Kumar, K. Gayathri, K. Tejaswi and P. Sudhir Babu. Topical 5‐Fluorouracil as Primary Treatment for Ocular Surface Squamous Neoplasia: A Case Series
Evaluation.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.5.574.578
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.5.574.578