Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Diabetes, hypertension, obesity and dyslipidemia are all recognized as contributing factors to metabolic syndrome (MS). Previous research has demonstrated a connection between each of these risk factors and heightened levels of inflammation. The present study aims to explore the relationship between oxidative stress and metabolic risk factors in ostensibly healthy adults. A cohort of ostensibly healthy adults (n = 165) was enlisted, with measurements taken for waist circumference, blood pressure, lipid profile, fasting blood sugar, serum glutathione (GSH) and hsCRP levels. Of these participants, 106 were identified with one or more metabolic risk factors (Group M), with a waist circumference exceeding 90 cm for males and 80 cm for females, while 59 individuals exhibited no metabolic risk factors (Group N). Subsequently, comparisons were made between serum hsCRP and GSH levels among the groups. Individuals with metabolic risk factors displayed heightened oxidative stress, as evidenced by elevated hsCRP levels and diminished serum GSH levels. These differences in hsCRP and GSH levels between the case and control groups were statistically significant. Additionally, our study identified elevated baseline hsCRP levels among the control group, consistent with findings from the AHA/CDC study. Our study suggests that Indians lacking metabolic risk factors for MS exhibit comparatively higher CRP levels and face an intermediate risk of cardiovascular disease. Furthermore, as the number of metabolic risk factors increases, hsCRP levels rise while serum GSH levels decline, indicating a positive association between the accumulation of risk factors and heightened oxidative stress.
How to cite this article:
Preeti Nigotia, Smita Doharey, Madhav Kadam and Shashank Tyagi. Association of Oxidative Stress with Metabolic Risk Factors in Apparently Healthy Adults A Correlative Analysis.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.5.533.536
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.5.533.536