files/journal/2022-09-03_18-51-40-000000_599.png

Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
About US
Editors
Issues
Pages
Indexed in
132
Views
14
Downloads

Study of Histopathological Spectrum and Immunohistochemical Profile of Primary Lung Carcinomas at a Tertiary Care Hospital in Rohilkhand Region of North India

Subhra Kumari, Nidhi Johri, Shanu Gupta, Shabana Andleeb Ansari, Surabhi Pandey and Azmat Kamal Ansari
Page: 496-501 | Received 31 Jan 2024, Published online: 12 Mar 2024

Download Citation
https://doi.org/10.36478/10.59218/makrjms.2024.5.496.501

Full Text Reference XML File PDF File

Abstract

Lung carcinoma is the most frequently diagnosed carcinoma in the world and one of the leading causes of cancer mortality worldwide. It is more commonly affecting males than females. Lung biopsies obtained by percutaneous route under radiological guidance is simple, rapid, easily accessible and reliable technique for the diagnosis of lung mass. Immunohistochemistry (IHC) can aid in accurate histological subtyping, which further decides molecular tests and treatment plans of patients. This is a retrospective observational study that included 133 lung biopsies diagnosed as lung carcinoma from January 2019 to June 2020 in the Department of Pathology, Shri Ram Murti Smarak (SRMS) Institute of Medical sciences (IMS), Bareilly. IHC markers p40, TTF1, CK7, Synaptophysin, Chromogranin and CD56 were performed on representative paraffin embedded sections. Only primary lung cancers were included in the study. The incidence of lung carcinoma was high in male patients with M:F ratio is 3.9:1. Out of 133 cases IHC markers were performed on 84 cases (84/133, 63.15%). P40 was positive in all the cases (24/24, 100%) of squamous cell carcinoma. Out of 24 cases of adenocarcinoma, 16 cases (66.6%) showed strong nuclear positivity for TTF1, while 8 cases (33.3%) revealed weak staining. CK7 was strong positive in all the cases of adenocarcinoma. Neuroendocrine markers were positive in all cases of small cell carcinoma. Histopathology, being the gold standard was found to be self sufficient in diagnosing most of the cases. However, immunohistochemistry is very helpful especially in cases with unusual pattern. We concluded that use of p40 for squamous cell carcinoma, TTF1 and CK7 for adenocarcinoma and synaptophysin, chromogranin and CD56 for small cell carcinoma are reliable markers and when used in combination can prove effective to arrive at correct diagnosis.

How to cite this article:

Subhra Kumari, Nidhi Johri, Shanu Gupta, Shabana Andleeb Ansari, Surabhi Pandey and Azmat Kamal Ansari. Study of Histopathological Spectrum and Immunohistochemical Profile of Primary Lung Carcinomas at a Tertiary Care Hospital in Rohilkhand Region of North India.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.5.496.501
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.5.496.501