Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Lipid lowering drugs like statins were shown to have protective effects on memory deterioration. The aim of the present study is to screen atorvastatin for spatial memory against aluminium induced neurotoxicity. The study included thirty male wistar rats, randomized, acclimatized under standard housing conditions. The ethics approval was obtained from institutional animal ethics committee. The drug dosing was done as per study plan and the effects were evaluated using behavioural parameters like Morris maze test, elevated plus maze test and rotarod test following standard methods. The atorvastatin showed significant improvement in Morris maze behavior (P=0.0002) and elevated plus maze behavior (P=0.0007). The results of this reveal the protective effects of atorvastatin on neurobehavioral activities against aluminium chloride toxicity.
How to cite this article:
Amir Alam and krishna Pandey. Effects of Atorvastatin on Spatial Learning and Motor Behavior Against Neurotoxicity Induced in Wistar Rats.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.5.492.495
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.5.492.495