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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Serum Biochemical Markers Combined With Uterine Artery Doppler during Second Trimester as a Predictor of Pre‐Eclampsia

Arpita Panda, Susanta Kumar Behera, Luzoo Prachishree, Pournava Pratyasa Pradhan and Sasmita Behuria
Page: 429-433 | Received 20 Jan 2024, Accepted 04 Mar 2024, Published online: 04 Mar 2024

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https://doi.org/10.36478/10.59218/makrjms.2024.5.429.433

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Abstract

Pre‐eclampsia is a pregnancy specific syndrome characterized by the onset of hypertension and proteinuria after the 20th week of gestation. It is the leading cause of the fetal growth restriction, premature delivery and is responsible for over 50,000 maternal deaths annually worldwide. To evaluate the association between abnormal levels of serum biochemical markers (Alpha Fetoprotein, ‐HCG, Uric Acid, Liver function test and Renal function test) combined with uterine artery Doppler in 2nd trimester in the prediction of pre‐eclampsia and eclampsia This Hospital based Prospective observational study was conducted in Department of Obstetrics and Gynecology S.C.B medical College and Hospital, Cuttack during the study period from March 2021‐March 2022 Our study showed that, mean Age of patients was [24.0865±4.2268], mean Gestational Age (Weeks/days)of patients was [19.9913±1.1747], mean BMI of patients was [24.0208±3.1991], mean MAP of patients was [86.7475±7.8911], mean Sr. ß‐HCG of patients was [31557.7212±17649.6158], mean Sr. LDH of patients was [441.2115±86.1059], mean Sr. AFP of patients was [87.0673±45.5231], mean Sr. Uric Acid of patients was [5.0615±1.4377], mean Sr. Bilirubin(Total) of patients was [.8875±.2606], mean Sr. Bilirubin(Direct) of patients was [.3825±.1464], mean Sr. Bilirubin (Indirect) of patients was [.5019±.2547], mean SGOT of patients was 25.2788±9.4216, mean SGPT of patients was[75.3654±27.2033], mean Sr. ALP of patients was [221.7788±52.5259], mean Sr. Urea of patients was [27.5962±8.1913], mean Sr. Creatinine of patients was [.6067±.1553], mean Sr. Sodium of patients was [137.8250±14.0400], mean Sr. Potassium of patients was [3.9481±.3066], mean Uterine Artery PI of patients was [1.1044±.1856]. Sr. ß‐HCG was higher in pregnant women with PE compared to without PE which was statistically significant. Sr. LDH was more in women without PE compared to with PE but this was not statistically significant. Sr. AFP was higher in women with PE compared to without PE but this was not statistically significant. Uterine Artery PI was more in women with PE compared to without PE which was statistically significant.

How to cite this article:

Arpita Panda, Susanta Kumar Behera, Luzoo Prachishree, Pournava Pratyasa Pradhan and Sasmita Behuria. Serum Biochemical Markers Combined With Uterine Artery Doppler during Second Trimester as a Predictor of Pre‐Eclampsia.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.5.429.433
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.5.429.433