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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Pediatric Non‐Hodgkin Lymphoma: A Cross‐Sectional Analysis of Histopathological Subtypes, Clinical Correlations, and Incidence of Hyperuricemia and Elevated LDH (Lactate Dehydrogenase) Levels

Uday Shankar Surabhi, Divya Poosarla, Ashok Babu Boddu and Penugonda Anveetha
Page: 402-405 | Received 22 Dec 2023, Published online: 16 Feb 2024

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https://doi.org/10.36478/10.59218/makrjms.2024.5.402.405

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Abstract

This study aims to provide a comprehensive cross‐sectional analysis of pediatric Non‐Hodgkin Lymphoma (NHL), emphasizing the distribution of histopathological subtypes, their clinical correlations, and the incidence of hyperuricemia. Understanding these associations is crucial for developing targeted therapeutic strategies and improving patient outcomes in the complexity of NHL in the pediatric population. A total of 65 pediatric patients diagnosed with NHL were enrolled in this study. Histopathological examination was conducted to classify the NHL subtypes. Clinical data were collected to explore correlations with histopathological findings. Biochemical parameters, including Lactate Dehydrogenase (LDH) levels and Serum Uric Acid, were measured to investigate their relationship with NHL. This cross‐sectional analysis utilized statistical methods to identify significant associations and trends. Our study identified diverse histopathological subtypes of pediatric Non‐Hodgkin Lymphoma (NHL), with significant clinical correlations to age, gender, and initial symptoms, underscoring the disease's complexity. Lymphoblastic and Burkitt's lymphomas were notably associated with specific demographic factors, highlighting the potential of age and gender in influencing disease subtype prevalence. Furthermore, we found a significant incidence of hyperuricemia (38.5%) and elevated LDH levels (46.2%) among the patients, suggesting these biochemical markers could serve as indicators of disease severity and metabolic effects. This analysis reveals the complex interplay between histopathological subtypes, clinical features, and biochemical markers in pediatric NHL, pointing to the utility of these markers in disease monitoring and risk stratification. It underscores the need for incorporating these parameters into patient management and calls for further research to explore their implications on outcomes and therapy optimization.

How to cite this article:

Uday Shankar Surabhi, Divya Poosarla, Ashok Babu Boddu and Penugonda Anveetha. Pediatric Non‐Hodgkin Lymphoma: A Cross‐Sectional Analysis of Histopathological Subtypes, Clinical Correlations, and Incidence of Hyperuricemia and Elevated LDH (Lactate Dehydrogenase) Levels.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.5.402.405
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.5.402.405