Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Platelets provide the first line of defence during the hemostatic process by formation of a hemostatic plug upon vessel injury that begins with apprehending circulating Platelets on exposed collagen and continues with the recruitment of additional Platelets into a growing Platelets mass that will eventually be stabilized with cross‐linked fibrinogen. Advances in platelet collection, storage and transfusion have decreased the morbidity of such therapies, and death form haemorrhage is now an unusual occurrence, despite the larger number of patients being treated aggressively. This study have shown comparable post transfusion increments, and haemostatic effect using the platelet components, however in all thrombocytopenic disorders platelets transfusion is not necessary but some time it is contraindicated. To evaluate and compare the role of Platelets transfusion in various thrombocytopenic disorders along with establishing the rationality of Platelets transfusion in various thrombocytopenic conditions. Hospital based prospective cohort study carried out in the Department of Pathology, N.S.C.B. Medical College and hospital Jabalpur, MP. Patients of all age group with thrombocytopenic disorder were included whereas Patient with haemophilia, related coagulation disorders and local infection at veni puncture site were excluded. Platelets separation was done By component separating centrigugal machine form multiple randomdonor. Platelets count was done by automated cell counter and Manually by neubaur’s chamber. In this study some routine tests were carried out before and after transfusion to test the haemostatic effect These test are‐ Bleeding Time, Clotting Time and Prothrombin Time. Out of 76 cases 48 were male and 28 were female, and in these maximum no of Cases were of 20 to 29 year of age. after platelets transfusion In Leukemia, Myelodisplastic Syndrome, Megaloblastic Anemia, Drug Induced Thrombocytopenia, Dengue patients, changes in Total leucocyte count, clotting time, Prothombin time is not significant (p value is more then 0.05). But in Platelets count and Bleeding time, significant changes occur ( p‐ value is less then 0.05). Platelets provide first line defence during haemostatic process by formation of a haemostatic plug upon vessel injury. Appropriate use of platelets transfusion is essential for prevention of bleeding because it can create many transfusion related problems.
How to cite this article:
Pushpraj Singh Baghel, Vishwanath Mohire, Chhavi Dwivedi and Kamal Raj Singh Baghel. Comparative Study‐Transfusion of Platelets in Various Thrombocytopenic Disorders.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.5.315.318
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.5.315.318