Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
The association between Decreased Vitamin D levels and non‐specific low back pain (Ns‐LBP) has been established. Nonetheless, there is limited understanding regarding the potential role of inflammation as a mediator in the relationship between Vitamin D levels and Ns‐LBP. To investigate the intervening effects of inflammatory markers (ESR and CRP) on the relationship between vitamin D levels and pain outcomes. Prospective study. Place of Study: Department of Orthopaedics of Raja Rajeshwari Medical College and Hospital, Bangalore. For this cross‐sectional investigation, participants were chosen, including individuals with non‐specific acute low back pain (Ns‐ALBP, n = 30) and non‐specific chronic low back pain (Ns‐CLBP, n = 30). Additionally, 60 individuals without non‐specific low back pain (Ns‐LBP) were selected as controls within the period from April 2023 to September 2023. The study involved the examination of serum 25(OH)D levels and ESR and CRP. To assess the potential mediating effects of inflammatory markers on the connection between vitamin D and pain, regression and causal mediation analyses were employed. The average serum concentrations of vitamin D among the control, Ns‐ALBP and Ns‐CLBP cohorts were determined to be 22.70±10.04, 18.44±8.46 and 15.25±8.05ng/mL, respectively (p<0.001). Following adjustments for clinical variables, a correlation was established between vitamin D deficiency and Ns‐LBP (p<0.05). According to mediation analysis, the overall mediated effect in Ns‐CLBP patients was estimated to be ‐0.461 (p<0.001). A Prospective analysis inherently carries potential biases. This study did not explore more sensitive bio‐markers. The assessment of pain intensity through the visual analogue scale unavoidably introduces a subjective element. Individuals experiencing Ns‐LBP exhibited reduced vitamin D levels and elevated ESR and CRP levels. Consequently, it is imperative to conduct extensive clinical trials to explore the practical effectiveness of vitamin D supplementation in mitigating inflammation and alleviating Ns‐LBP.
How to cite this article:
K.M. Sandeep, K.B. Monesh and Adithya Reddy. The Role of Inflammatory Markers as a Mediator Between Vitamin D and Non‐specific Low Back Pain: A Prospective Study.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.5.237.242
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.5.237.242