Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Armand Trousseau’s 1865 report established the association between cancer and thrombosis. Globally, cancer causes significant mortality, with India reporting 8,08,558 deaths in 2022. Solid organ malignancies exhibit diverse coagulation changes, predisposing individuals to thromboembolic events. This study aims to investigate alterations in haemostatic parameters and their association with cancer. A prospective observational study included 100 cases (60 malignant, 20 benign and 20 healthy controls). Haematological and coagulation parameters, including platelet count, PT, APTT and D‐dimer, were assessed. Statistical analysis involved descriptive statistics ×2‐test and independent sample t‐tests. In malignancies, 73.33% exhibited coagulation abnormalities, with elevated platelet counts, prolonged PT and APTT and 73.33% showing D‐dimer levels >200 ng/mL. The study revealed 67.44% compensated, 23.25% overcompensated and 9.30% decompensated ICF in malignancies. Thrombocytosis was observed in 23.25%. Statistical analyses demonstrated significant differences between malignant and benign groups. The study supports the intricate interaction between cancer and the hemostatic system. Elevated D‐dimer levels emerged as a universal indicator, reflecting a more aggressive malignant process. Despite the established link between cancer and thrombosis, anticoagulation is not standard, necessitating improved management strategies. Understanding the coagulation profile in cancer aids in predicting and managing complications, emphasizing the importance of assessing D‐dimer levels in malignancies.
How to cite this article:
Bhoomika Chaudhari, Asha J. Satvara and Samir Bhagora. Coagulation Profile in Neoplastic Conditions: A Prospective Observational Study.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.5.209.214
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.5.209.214