Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
The episodes of auto‐immune diseases is increasing in alarming rate these days. Despite of accurate and advance diagnostic facilities management of diseases is out of control and remained chronic diseases. The management of disease requires long‐term treatment with harmful agents, such as Methotrexate or other immuno‐suppressive drugs. The net side effects produced from Methotrexate are based on the duration of treatment and cumulative concentration of the drug. The major pulmonary adverse effect of methotrexate is interstitial pneumonitis. There are several evidences of pulmonary function defects in patients receiving methotraxate at low level but for longer period of disease. The present study was undertaken to analyse the findings found on chest x‐rays, high resolution computed tomography (HRCT) and pulmonary function tests (PFT) in a cohort of patients without previous recognized interstitial lung disease. The studied patients were receiving methotrexate as a treatment for psoriatic arthritis, a condition not associated with pleuropulmonary disease. The incidence of pulmonary toxicity in psoriasis patients taking Methotrexate on long term basis. This is a cross sectional study done in Department of Pulmunory Medicine of our Institute during the period from March 2022‐2023. Fivety patients chosen for our study were clinically diagnosed with Psoriasis and were on methotrexate therapy for >3 months (cumulative dosage exceeding 150 mg). All the patients were subjected to detailed history taking, clinical examination, complete haemogram, liver function test, renal function test, spirometry, diffusion capacity of carbon monoxide and radiological examination including x‐ray chest and HRCT Chest (read by 2 independent readers).The data were tabulated and analysed. we conclude that the frequency of development of advanced pulmunory toxicity on methotrexate therapy for psoriasis is small in low‐risk subjects and methotrexate alone is not responsible for the progressive lungs disease. Methotrexate therapy, psoriasis, lungs disease.
How to cite this article:
Sundiep Kumar, Jaishree Noor and Supriya Agarwal. Methotrexate Induced Pulmonary Toxicity in Psoriasis Patients.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.5.168.171
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.5.168.171