Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
The term “urethral stricture” describes the constriction of the urethra brought on by scarring, which obstructs the lower urinary system. Numerous conditions, including iatrogenic, trauma, urethritis, Blanitis Xerotica Obliterans (BXO) and idiopathic, can cause it. To evaluate the impact of topical tacrolimus administration in cases of BXO‐induced urethral stricture and the potential side effects. The present study was a Prospective observational study. This study was conducted form 18 months in in the Department of Urology, NSMCH, Bihta, Patna. All patients meeting the eligibility criteria was treated with a local application of 0.1% tacrolimus twice daily for 6 weeks. 100 patients were included in this study. After the catheter removal Peak flow was 23.8 ml/sec, 18.2 ml/sec at the 3 month follow‐up and 17.75 ml/sec at the 6‐month follow‐up. Average flow in our study was 15.6 ml/sec following catheter removal, 13.8 ml/sec at the follow‐up after three months and 15.5 ml/sec at the follow‐up after six months. In our investigation, the voided volume was 278 ml following catheter removal, 235 ml at the 3 month follow‐up and 288 ml at the 6‐month follow‐up. BXO‐induced urethral stricture was evident in the Qmax values, which decreased from 28.8 ml sec after catheter removal to 17.62 at 6 months. Our study found a significant decrease in peak flow and related parameters after catheter removal and subsequent follow‐up. Peak flow dropped from 28.8 ml/sec after catheter removal to 17.62 after 6 months. The same period saw average flow drop from 19.75‐12.75 ml/sec and voided volume drop from 278‐283ml. Patients also experienced pruritis (8.8%) and rash (5.0%). Peak flow levels and associated indicators decreased significantly, suggesting the underlying illness may be progressing.
How to cite this article:
Shivanand Prakash, M. Mahesh, Vinod Kumar, Md. Faizan Sarwar and Arshad Hasan. Effect of Topical Tacrolimus in Patients of Non Obliterative Anterior Urethral Stricture Due to BXO.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.5.145.149
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.5.145.149