Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
Diabetes mellitus is a global health concern characterized by hyperglycemia, necessitating innovative therapeutic strategies. Inhibition of carbohydrate‐digesting enzymes, particularly a‐amylase and a‐glucosidase, is a promising approach to control postprandial blood glucose levels. Bacopa monnieri (BM), a renowned medicinal herb with a rich phytochemical profile, has gained attention for its potential anti‐diabetic properties. This study explores the inhibitory potential of a bioactive fraction of Bacopa monnieri on a‐amylase and a‐glucosidase enzymes, offering insights into its role as an in‐vitro therapeutic agent for anti‐diabetic activity. the preliminary phytochemical screening of leaf extracts of Bacopa monnieri results showed the presence of alkaloids, terpenoids, phenols, carbohydrates and flavonoids. The TLC from solvent systems 7:3 hexane Ethyl acetate, 9:1 chloroform methanol and 9.5:0.5 ethyl acetate methanol showed clear band separation of compounds in all crude fractions. The other characterizations FTIR and LCMS were also carried out. This research sheds light on the promising role of Bacopa monnieri as an in‐vitro therapeutic agent for anti‐diabetic activity through the inhibition of a‐amylase and a‐glucosidase enzymes. Further exploration, including in‐vivo studies and clinical trials, is warranted to validate its efficacy and safety as a complementary approach in managing diabetes mellitus.
How to cite this article:
Rajagopal Kanagalatha and Venugopal Tamilselvi. Inhibitory Potential of A‐Amylase and A Glucosidase Enzymes by Bioactive fraction of Bacopa Monnieri: In Vitro study for Anti Diabetic Activity.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.5.101.108
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.5.101.108