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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Cross‐Sectional Study of Antioxidant Enzyme Activities in Diabetic vs Non‐Diabetic Individuals

Vishnu Pandurangra Kankute, Ashwini Shankarrao Jadhav, Shubhangi Gajanan Umbarkar and Vikas Madan Rathod
Page: 15-19 | Received 21 Nov 2023, Published online: 27 Dec 2023

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https://doi.org/10.36478/10.59218/makrjms.2024.3.15.19

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Abstract

This study investigates the comparative activities of antioxidant enzymes in diabetic versus non‐diabetic individuals, aiming to understand the impact of diabetes on oxidative stress mechanisms. Methods: Utilizing a cross‐sectional design, this research examined 200 participants, divided equally between diabetic and non‐diabetic groups. The focus was on measuring the activities of key antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Participants were matched for age and sex and enzyme activity levels were quantified using standardized biochemical assays. The analysis, as depicted in the tables, demonstrates a notable reduction in the activities of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (Gpx) among individuals with diabetes compared to those without the condition. Specifically, the activities of SOD, CAT, and GPx were significantly lower in the diabetic group, with respective percentages of optimal activity at 40‐45‐35%, compared to 80%, 85‐75% in the non‐diabetic group. The odds ratios (OR) further substantiate the considerable disparities, indicating an increased likelihood of reduced enzyme activity in the diabetic cohort. These results underscore a pronounced difference in oxidative stress response between diabetic and non‐diabetic individuals, reflecting an impaired antioxidant defense mechanism in those with diabetes. The study concludes that individuals with diabetes have significantly lower activities of key antioxidant enzymes, indicating a weakened oxidative defense system that may contribute to increased oxidative stress. This reduction in enzymes like superoxide dismutase, catalase, and glutathione peroxidase emphasizes the critical role of oxidative stress in diabetes. The findings necessitate further research into targeted antioxidant therapies, suggesting that such treatments could improve oxidative stress management in diabetic patients, thereby enhancing their overall health and quality of life.

How to cite this article:

Vishnu Pandurangra Kankute, Ashwini Shankarrao Jadhav, Shubhangi Gajanan Umbarkar and Vikas Madan Rathod. Cross‐Sectional Study of Antioxidant Enzyme Activities in Diabetic vs Non‐Diabetic Individuals.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.3.15.19
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.3.15.19