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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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A comparative Study of Intrathecal Morphine and Clonidine as Adjuvant to Hyperbaric Bupivacaine in Infraumbilical Surgical Procedures Under Spinal Anaesthesia

Shuvojit Roy, Krishnendu Chandra, Krishna Poddar and Asis Patra
Page: 154-159 | Received 14 Aug 2023, Published online: 05 Sep 2023

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https://doi.org/10.36478/10.59218/makrjms.2023.8.154.159

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Abstract

Spinal anesthesia is the most commonly used technique for lower abdominal surgeries as it is very economical and easy to administer. However, postoperative pain control is a major problem because spinal anesthesia using only local anesthetics is associated with relatively short duration of action and thus early analgesic intervention is needed in the postoperative period. Comparison of efficacy of intrathecal low dose morphine and clonidine as adjuvant to hyperbaric bupivacaine to provide postoperative analgesia in infra umbilical surgeries. This prospective, randomized, double blinded comparative study was conducted in ramakrishna mission seva pratishthan, vivekananda institute of medical sciences, Kolkata after obtaining clearance from Institutional ethical and scientific committee. Study duration was August 2020‐2021. All patients were randomly allocated into two groups (group BM‐BC) with 40 patients in each group. Total 80 patients taken and divided in two groups. Group‐BM 40 patients and group‐BC 40 patients. In group‐BC, 27 (67.5%) patients had no mephentermine injection, 8 (20.0%) patients had 1 mephentermine injection and 5 (20.0%) patients had 2 such. In group‐BM, 37(92.5%) had no mephentermine injection and 3 (7.5%) patients had 2 such. Association of number of mephentermine injection vs groups was statistically significant (p = 0.0121). In group‐BC, the mean time of 1st rescue analgesic of patients was 329.0250±51.0191. In group‐BM, the mean time of 1st rescue analgesic of patients was 884.4750±188.9127. Distribution of mean time of 1st rescue analgesic with group was statistically significant (p<0.0001). Overall, intrathecal morphine did not increase respiratory depression. Intrathecal morphine was associated with a mild increase in vomiting but clonidine was associated with a mild increase in hypotension. To conclude, intrathecal morphine decreases pain intensity at rest and on movement up to 24 hrs after major surgery. Morphine‐sparing is more pronounced after abdominal, gynecological and orthopedic surgery. Respiratory depression remains a major safety concern.

How to cite this article:

Shuvojit Roy, Krishnendu Chandra, Krishna Poddar and Asis Patra. A comparative Study of Intrathecal Morphine and Clonidine as Adjuvant to Hyperbaric Bupivacaine in Infraumbilical Surgical Procedures Under Spinal Anaesthesia.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.8.154.159
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.8.154.159