Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Chronic Kidney Disease (CKD) is increasingly recognized for its association with various metabolic disturbances, including dyslipidemia. The impact of age and disease progression on lipid profile remains of considerable interest, with potential implications for cardiovascular risk assessment and therapeutic intervention. To analyze the fasting lipid profile of CKD patients, evaluate its correlation with kidney function and ascertain the clinical significance of observed lipid abnormalities. A cross‐sectional study was conducted on 100 CKD patients aged 40‐80 years. Lipid parameters including total cholesterol, LDL, HDL and Triglycerides were assessed and associations with kidney function, specifically eGFR, were determined. The mean age of the participants was 58 years with a male predominance (55%). The average Total Cholesterol was found elevated at 220 mg dL-1. LDL stood at a concerning 140 mg dL-1, while HDL was borderline with a mean of 40 mg dL-1. Triglycerides further emphasized dyslipidemia with a mean of 180 mg dL-1. Alarmingly, 70% of patients had cholesterol levels above 200 mg dL-1 and 60% exhibited elevated LDL levels. Notably, 50% of patients in advanced CKD stages had exacerbated lipid abnormalities. A significant negative correlation was observed between eGFR and Total Cholesterol (r = ‐0.65), while a positive correlation existed between deteriorating CKD stages and rising triglycerides (r = 0.5). CKD patients demonstrate a prominent trend of dyslipidemia, escalating with disease progression. This study accentuates the imperative need for routine lipid monitoring and tailored interventions in the CKD population, potentially mitigating associated cardiovascular complications and improving patient outcomes.
How to cite this article:
Dharavath Bhanu Prakash, Dulam Pradeep Kumar and Ponnala Suresh. The Interplay Between Chronic Kidney Disease and Fasting Lipid Levels: A Comprehensive Study.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.8.104.108
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.8.104.108