Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Non‐alcoholic fatty liver disease (NAFLD) has become a leading cause of chronic liver disease globally, with diverse histopathological manifestations. This study aims to describe the histopathological patterns of NAFLD in patients at a tertiary care center. To assess and categorize the histopathological patterns of liver biopsy specimens from patients diagnosed with NAFLD and correlate with clinical and laboratory parameters. A cross‐sectional study was conducted, analyzing liver biopsy specimens of 250 patients diagnosed with NAFLD at a tertiary care center over a period of 12 months. Histopathological findings were categorized based on the NAFLD activity score (NAS) and fibrosis staging. Clinical and laboratory parameters, such as age, gender, BMI, liver enzymes and lipid profiles, were correlated with histopathological findings. Steatosis was observed in 100% of the biopsies. Non‐alcoholic steatohepatitis (NASH) was identified in 60% of cases, with 30% showing advanced fibrosis (stage 3‐4). A significant correlation was found between elevated liver enzymes and the severity of NASH. Additionally, higher BMI was associated with greater fibrosis. The histopathological patterns of NAFLD are diverse, with a substantial percentage of patients demonstrating NASH and advanced fibrosis. Clinical and laboratory markers can be indicative of the severity of histopathological changes. Early recognition and management are crucial to prevent progression to cirrhosis and its complications.
How to cite this article:
R. Palaniswamy. Histopathological Patterns of Non‐alcoholic Fatty Liver Disease: A Cross‐Sectional Study in a Tertiary Care Center.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.726.730
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.726.730