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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Assessing the Relationship between HBV DNA, HBeAg and ALT Levels in Patients with Chronic Hepatitis B

Ketha Venkateswarlu, Jyothi Pendyala, Vanisree Dasari, Ravi Kiran Koppolu and Lokeshu Talapagala
Page: 1125-1130 | Received 14 May 2023, Published online: 24 Jul 2023

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https://doi.org/10.36478/10.59218/makrjms.2023.7.1125.1130

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Abstract

Chronic Hepatitis B (CHB) caused by the Hepatitis B virus (HBV) is a major global health concern with a substantial disease burden. CHB contributes to over 240 million chronic infections and approximately 600,000 deaths annually. Understanding the factors associated with CHB progression is crucial for effective management. This study aimed to investigate the correlation between HBV DNA levels, Hepatitis B e‐Antigen (HBeAg) status and Alanine Aminotransferase (ALT) levels in 200 clinically and serologically confirmed CHB patients. A cross‐sectional study was conducted at the Departments of Microbiology and Gastroenterology, Guntur Medical College/Government General Hospital, Guntur. The study enrolled 200 CHB patients whose diagnoses were both clinical and serological. Serum ALT levels were quantified using an automated Beckman Coulter system. HBeAg was detected through Chemiluminescence Microparticle Immunoassay (CMIA) and HBV DNA levels were measured using real‐time PCR with the Alto Star HBV PCR Kit. Among the CHB patients, 68% were male, with the predominant age group being 31‐40 years (32%). HBV DNA was detected in 14.5% of cases, 21% tested positive for HbeAg and 28% had abnormal ALT levels. Notably, 21% of patients were positive for both HBeAg and HBV DNA and they exhibited abnormal ALT levels. However, 8% of patients had abnormal ALT levels despite being HBeAg negative and having undetectable HBV DNA. This study underscores a significant association between HBV DNA levels, HBeAg status and ALT elevations in CHB patients. Elevated HBV DNA levels were more frequent in HBeAg‐positive patients, who consistently displayed raised ALT levels. Concurrent monitoring of these markers is essential for effective CHB management, facilitating timely intervention and better patient outcomes in this global health concern. Chronic hepatitis B, HBV DNA, HBeAg, alanine aminotransferase, ALT.

How to cite this article:

Ketha Venkateswarlu, Jyothi Pendyala, Vanisree Dasari, Ravi Kiran Koppolu and Lokeshu Talapagala. Assessing the Relationship between HBV DNA, HBeAg and ALT Levels in Patients with Chronic Hepatitis B.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.7.1125.1130
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.7.1125.1130