Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
Mastalgia in woman is a major factor in missed work days and occasionally, the inability to complete daily tasks. A majority of these patients have disorders of normal development and involution (ANDI), more especially fibrocystic disease. Nearly 10‐15% of lesions regress spontaneously over period of 6‐60 months. Up until this point, only tamoxifen has been used. If efficacy is well established, Tablet Saheli (ormeloxifene), which is less expensive, readily available and has few adverse effects, will likely become the medication of choice for these individuals. Aim of the study was to investigate the role of Centchroman in regression of fibroadenosis in comparison to natural observation and study the association of hormonal receptors with degree of regression. At the Civil Hospital in Ahmedabad, a prospective study involving 60 patients with fibrocystic breast disease and mastalgia was conducted from July 2020 to June 2023. Patient with congenital abnormalities, infectious diseases and benign breast disorders like fibroadenoma were excluded. Our research's objective was to examine the efficacy of several medications frequently prescribed for fibroadenosis and mastalgia. About 60 individuals were taken in study, 30 received Tab. Saheli (ormeloxifene), 26 received evening primrose oil and 4 received danazol. About 18 patients out of 30 got a full response to Tab Saheli (ormeloxifene), or 60% of the patients. About 50% (13 patients) of the 26 patients who started taking evening primrose oil and 50% (2 patient) of the 4 patients who started taking danazol had a full recovery. Even six months later, the remaining 27 (35%) patients' problems remained unrelieved.
How to cite this article:
Apurva G. Shah, Florina Malek and Nirmala Ganapathy. Study of Various Drugs in Aberration of Normal Development and Involution of Breast and
Fibroadenosis.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.463.466
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.463.466