Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Comparison of Platelets, Lymphocytes, Eosinophils as a Prognostic Marker in Perforation Peritonitis and Correlation with JPSS
Dhananjay Majhi, Vineet Dwivedi, Sanjay Dev Vishwakarma, Kuldip Pratap Patel and Ravi Pratap Singh
Page: 276-285 | Received 13 Jun 2023, Accepted 20 Jun 2023, Published online: 02 Jul 2023
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Abstract
Perforation peritonitis is one of the most common surgical emergencies in India and is a common form of acute intrabdominal infection that results from the perforation of a viscous. Several factors associated with mortality were taken into consideration such as age, presence of co‐morbidities, Perforation to operation interval, preoperative shock, heart rate, serum creatinine. Each factor was given score based on its severity to construct the simplified prognosis or Jabalpur prognostic scoring system (JPSS). This is a prospective, observational, comparative, single center study to be carried out in N.S.C.B. Medical college and hospital Jabalpur Department of General Surgery in time period of two years. Aims are‐ comparison of platelets, lymphocytes, eosinophils as a prognostic marker in perforation peritonitis and correlation with JPSS. Secondary aim of study is to aid the physician in better prognosis and treatment for perforation peritonitis. All patients diagnosed with perforation peritonitis is to be included in the study. Minimum 60 patients are to be enrolled in the study from November 2019 to August 2021. Age, gender and length of stay in the hospital will be recorded. Furthermore, the measurements of the blood haemoglobin level, leukocyte, neutrophil, lymphocyte and eosinophils which will be obtained from the patients’ medical case record. In the evaluation of the sensitivity and specificity of the parameters in diagnosis and to predict prognosis, the ROC curve test to be used (p<0.05). The analysis of 84 cases of hollow viscous perforation, who underwent emergency laparotomy. In the study, out of 84 cases 83.4% were male and 16.6% were female, most common age group affected was 46‐55 (25%). mean age 43.3 +/‐SD 15.047. Most common site of perforation found to be prepyloric in 61.9% male and 10.77% female next most common site observed was ileum in 16.7%male and 1.19% female. Other sites comprise were Gall bladder (1.2%), Duodenum (1.2%), Jejunum (1.2%), Appendix (1.2%), caecum (1.2%), ascending colon (1.2%), transverse colon (2.4%). The JPS calculated on preoperative day, post operative day 1,2,3,5, and 7, respectively. The JPS was <5 in 48.8, 58.3, 61.9, 65.5, 66.7 and 71.4% patients on preoperative day, post operative day 1,2,3,5 and 7 respectively. JPS was 6‐10 in 46.4, 36.9, 32.1, 29.8, 27.4 and 21.4% patients on preoperative day, post operative day 1, 2, 3, 5 and 7, respectively. The JPS was 11‐15 in 3.6, 3.6 and 2.4%, patients on pre‐operative day, post operative day 1, 2 and 3, respectively. In this study platelets count have shown rising trend as post operative days passes without any statistically significant variation. Same trend has also seen in lymphocyte count after second post operative day with persistent rise in mean value of it, without any statistically significant variation. Absolute eosinophil count has shown very minimal, irregular, statistically not significant change as post op days passed. Among platelets, lymphocytes and eosinophil, platelet count and lymphocytes can be used as a reliable marker in early detection of sepsis.
How to cite this article:
Dhananjay Majhi, Vineet Dwivedi, Sanjay Dev Vishwakarma, Kuldip Pratap Patel and Ravi Pratap Singh. Comparison of Platelets, Lymphocytes, Eosinophils as a Prognostic Marker in Perforation Peritonitis and Correlation with JPSS.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.276.285
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.276.285