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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Effect of Dexmedetomidine on Haemodynamic Response and Agitation Score in Modified Electro Convulsive Therapy (ECT): A Prospective Double-Blind, Randomized Controlled Trial

Meenu Sharma, Komal S. Shah, Venu Gandhi and Maya Damor
Page: 202-208 | Received 15 Jun 2023, Published online: 29 Jun 2023

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https://doi.org/10.36478/10.59218/makrjms.2023.202.208

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Abstract

Electroconvulsive therapy (ECT) is a beneficial treatment for individuals with psychological disorders who may reject medication. This study aimed to investigate the effects of dexmedetomidine compared to a placebo as pre-treatment options on the hemodynamic parameters and emergence of patients undergoing ETC. A prospective, randomized and double-blinded trial was conducted, involving a total of 60 participants who were equally divided into two groups. Group N received a 10 min intravenous infusion of 100 mL of normal saline. Group D received a 10 min intravenous infusion of dexmedetomidine at a dose of 1 µg kg‾1, diluted to a total volume of 100 mL. Various parameters, including heart rate (HR), mean arterial pressure (MAP), seizure duration, agitation score and time to discharge, were evaluated by the researchers. In Group N, the recorded heart rates at 5 and 10 min after the electrical stimulus were 113.30±18.79 and 111.37±15.58 beats per minute, respectively. In contrast, Group D exhibited heart rates of 93.63±14.83 and 94.57±20.15 beats per minute at the same time points, showing a significant difference (p<0.0001). Systolic blood pressure measurements after 5 min of ECT were 116.53±26.09 mmHg in Group D and 138.03±19.32 mmHg in Group N, indicating a significant difference (p<0.001). Diastolic blood pressure and mean arterial pressure were notably reduced in Group D following the induction and electrical stimulus. The duration of seizures was similar between both groups. Additionally, Group D showed an improvement in the Richmond Agitation-Sedation Score. Dexmedetomidine effectively mitigates the impact on hemodynamic parameters during ECT, resulting in decreased emergence agitation without adverse effects on seizure duration or other complications. The administration of dexmedetomidine successfully attenuates changes in hemodynamic responses during ECT while also alleviating emergence agitation, without affecting the duration of seizures or introducing additional complications.

How to cite this article:

Meenu Sharma, Komal S. Shah, Venu Gandhi and Maya Damor. Effect of Dexmedetomidine on Haemodynamic Response and Agitation Score in Modified Electro Convulsive Therapy (ECT): A Prospective Double-Blind, Randomized Controlled Trial.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.202.208
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.202.208