Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Ovarian carcinoma is a heterogeneous disease. Each of these categories is associated with different genetic risk factors and molecular events during oncogenesis and they also differ dramatically in frequency. Present study was aimed to study different ovarian malignancies based on histopathology and expression of CD44 in malignant surface epithelial tumors of ovary at a tertiary hospital. Present study was single‐center, descriptive study conducted all specimens of ovarian carcinoma received in the department during the study period. All cases of malignant surface epithelial tumors were subjected to study of immunohistochemical marker CD44. In present study 204 cases of ovarian malignancies were studied. Majority patients were from age‐group of 51‐60 years (38.23%) followed by age‐group of 61‐70 years (22.55%). Only around 13% of the patients were premenopausal, majority were postmenopausal (66.17%). There were 187 cases (91.17%) of surface epithelial tumors. Based on histopathology most common type was serous carcinoma (42.15%), followed by mucinous carcinoma (17.64%), endometroid carcinoma (20.6%) and clear cell carcinoma (8.33%). Majority of the patients presented at stage I, closely followed by patients at stage II. In our study, 35 cases of surface epithelial carcinomas were selected for CD44 expression study. This include 17 cases of serous carcinomas, 5 cases of mucinous carcinomas, 7 cases of endometroid carcinomas, 4 cases of clear cell carcinomas and 2 cases of seromucinous carcinomas. The positive staining of CD44 showed cellular membrane localization. 15 cases showed strong CD44 positivity, 9 cases showed moderate positivity and 7 cases showed weak positivity. From our study we conclude that the surface epithelial carcinomas constituted the major part of ovarian malignancies. We also noticed a positive correlation between tumor grade and CD44 positivity.
How to cite this article:
M. Sithalakshmi, Jinu T. Eldho, Nithya Jayakumar and Sunayana Mathew. Study of Different Ovarian Malignancies Based on Histopathology at A Tertiary Hospital.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.12.77.82
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.12.77.82