Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
The primary symptoms are pain and stiffness of the affected joints, secondarily leading to joint dysfunction, deformities, and muscular weakness. It is the most common form of arthritis with approximately 250 million people worldwide conservatively estimated to be suffering from osteoarthritis of the knee alone. We, therefore, thought it worthwhile to compare the efficacy and tolerability of oxaceprol, in comparison to the relatively weak opioid tramadol, in the treatment of symptomatic knee osteoarthritis. The study protocol was approved from institutional ethical committee. All patients were informed regarding the study and written consent was obtained. General information such as name, age, gender etc. was recorded. A careful examination was done in all patients. Patients were divided into 2 groups. Group I received oxaceprol 200 mg capsule and group II or tramadol 50 mg capsule, thrice daily for 12 weeks. Patients were recalled regularly. Mean WOMAC score pain in group I was 258 which decreased to 228 in group I and 253 which decreased to 203 in group II. The difference was significant (p<0.05). WOMAC stiffness score in group I was 27.1 which decreased to 21 in group I and 29.2 which decreased to 23.3 in group II. WOMAC physical function score in group I was 916 which decreased to 728 in group I and 892 which decreased to 780 in group II. The difference was significant (p<0.05). Both drugs found to be equally effective in management of cases.
How to cite this article:
Subhash Jain, Sandeep Garg and Mohan Lal Bilani. A Clinical study on Management of Osteoarthritis.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.12.184.187
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.12.184.187