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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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A Study of Antineutrophil Cytoplasmic Antibody Profile in Systemic Lupus Erythematosus Patients with Reference to Disease Activity and Organ Involvement

Sonali Dey, Diganta Das, Sanjeeb Kakati and Priyanka Priyadarshini Baishya
Page: 55-64 | Received 25 Sep 2023, Published online: 11 Oct 2023

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https://doi.org/10.36478/10.59218/makrjms.2023.11.55.64

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Abstract

Systemic lupus erythematosus (SLE) is characterized by a diverse array of clinical presentations, warranting comprehensive analyses to decipher the potential correlations between disease activity scores, complement levels and autoantibodies prevalence. In this cross‐sectional study spanning a period of 12 months, we investigated the correlation between disease activity, hypocomplementemia and various autoantibodies in 200 patients with systemic lupus erythematosus (SLE) at a tertiary healthcare center. Utilizing various clinical and laboratory markers, we aimed to construct a detailed understanding of the disease patterns and manifestations, which might foster more precise management and intervention strategies for individuals afflicted with SLE. A significant segment of the study population showcased moderate to high disease activity, with 37.50% displaying SLEDAI scores between 11‐20. A notable correlation was observed between low complement C3 levels and the presence of dsDNA antibodies (77.7%). Moreover, the presence of antidsDNA was significantly associated with higher disease activity scores, reaffirmed by a p‐value of 0.007. The findings underscore the pivotal role of complement levels and specific autoantibodies as potential markers for monitoring disease activity in SLE patients. These parameters could potentially guide the development of personalized therapeutic strategies, fostering improved management of SLE.

How to cite this article:

Sonali Dey, Diganta Das, Sanjeeb Kakati and Priyanka Priyadarshini Baishya. A Study of Antineutrophil Cytoplasmic Antibody Profile in Systemic Lupus Erythematosus Patients with Reference to Disease Activity and Organ Involvement.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.11.55.64
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.11.55.64