Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Laparoscopic cholecystectomy requires the creation of a pneumoperitoneum via insufflations of carbon dioxide, which may result in adverse haemodynamic disturbances leading to visceral organ ischaemia including hepatic dysfunction. There have been few studies in tertiary care hospital to evaluate the potential harmful effects of laparoscopic surgery on hepatic function. This study was intended to assess the alteration and clinical significance of unexplained disturbances in liver enzymes following laparoscopic cholecystectomy. And to correlate the duration of laparoscopic surgery and the causes and clinical significance of unexplained disturbances in liver enzymes. To study the liver enzymes and its variation post laparoscopic cholecystectomy in tertiary care hospital. This is a prospective observational study was conducted in teriary care hospital, comprised of 30 patients, of symptomatic cholelithiasis and in all patient laparoscopic cholecystectomy was done between 1st May 2021 to 1st May 2022. In all the patients, liver function tests were done pre-operatively and post operatively (within 24 hrs). The obtained data was analysed for effect of laparoscopy cholecystectomy on liver function test of the patients. Twenty-four hours after the procedure the mean liver enzymes were raised, there was statistically significant elevation of AST (70.46, p<0.001) and ALT (79.00, p<0.001) . But the raise was transient and fell off to normal or near normal levels in 7-10 days postoperatively. In conclusion, transient mild abnormality in liver function tests is a usual finding after laparoscopic cholecystectomy without clinical significance. It is mainly attributed to the high intraabdominal pressure of carbon dioxide pneumoperitoneum, which may compromise the hepatic blood flow causing alterations in the microcirculation but a proper reason has still not been established. Hence it is always better to have a close monitoring of the liver enzymes during the procedure laparoscopic cholecystectomy.
How to cite this article:
V. Shilpa, Anil Kumar, Robin Prabhu and Varun B. Gulgi. A Study of Liver Enzymes Analysis Following Laparoscopic Cholecystectomy in A Tertiary Care Hospital.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.11.223.226
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.11.223.226