Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
The subarachnoid block is a preferred technique of anesthesia as it is easy to carry out, the onset of action is rapid, better relaxation of muscle and effectual but its duration of action is short. Adjuvants are drugs that increase the efficacy or potency of other drugs when given concurrently. Present study was aimed to compare nalbuphine and dexmedetomidine as adjuvant to intrathecal bupivacaine on spinal anaesthesia Present study was comparative, randomized, interventional study, conducted in patients 21-60 years age, ASA grade I/II, scheduled for elective infraumbilical surgeries under spinal anesthesia. In present study, 60 patients were randomly assigned into Group N (received 3 mL of 0.5% of bupivacaine +0.8 mg of nalbuphine) and Group D (received 3 mL of 0.5% levobupivacaine and 5 μg dexmedetomidine). Early onset of sensory block (2.22±1.12 min vs 3.25±1.24 min), early onset of motor block (4.3±1.3 min vs 6.7±2.62 min), less time to reach maximum level of sensory block (6.2±2.12 min vs. 8.3±2.9 min), more total duration of motor block (182.28±31.65 min vs. 151.48±38.66 min), late first request for rescue analgesia (281.43±44.57 min vs. 211.78±49.88 min) and delayed two segments regression (102.65±21.54 min vs. 83.35±25.6 min) was noted in dexmedetomidine group as compared to nalbuphine group and difference was statistically significant. Intraoperative and Immediate post-operative complications such as hypotension, bradycardia, vomiting, pruritis and shivering were more in nalbuphine group but difference was not statistically significant. Dexmedetomidine as adjuvant to intrathecal bupivacaine in spinal anaesthesia had prolonged duration of motor block, prolonged time of two segments regression and reduced demand for rescue analgesics as compared to nalbuphine as adjuvant to intrathecal bupivacaine.
How to cite this article:
Bhavesh K. Dalwadi and Payal Kalpesh Berawala. Comparative Study of Nalbuphine and Dexmedetomidine as Adjuvant to Intrathecal Bupivacaine in Spinal Anaesthesia.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.1013.1017
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.1013.1017