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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Clinical Profile of Hypothyroid Adults in Reproductive Age Group and Its Correlation with Serum Vitamin D and Calcium Levels at a Tertiary Care Hospital

J.P. Vinay and C.N. Tejaswi
Page: 34-37 | Received 18 May 2023, Accepted 16 Nov 2022, Published online: 02 Dec 2022

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https://doi.org/10.36478/10.59218/makrjms.2022.34.37

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Abstract

Hypothyroidism is a result of deficiency of thyroid hormones. Mineral metabolism (calcium, vitamin D and phosphorous) is disturbed in thyroid disorders. Both vitamin D and thyroid hormone bind to steroid hormone receptors. Vitamin D receptor gene polymorphism is found to be associated with autoimmune thyroid diseases. To assess the clinical profile of hypothyroid patients in reproductive age group and correlate hypothyroidism with vitamin D and calcium levels. A total of 100 patients with newly detected or untreated hypothyroidism were studied. After a detailed history and  clinical  examination,  laboratory  parameters such as serum TSH, free T4, serum vitamin-D, serum  calcium  levels were assayed.  Among   100   patients  there  was  a  female  preponderance (71 females) of hypothyroidism. The mean age group of study population was 39.76+8.57 years, with 24 sub-clinical hypothyroidism and 76 clinical hypothyroidism cases. The most common symptoms and signs  in females were menstrual abnormality (73.2%) and fatigue (57.7%). In males, most common presentation was fatigue (65.5%) and hair loss (48.2%). The mean serum vitamin D levels in sub clinical hypothyroid patients was 24.33+4.15 ng mL‾1 and in clinical hypothyroid was 20.38+5.10 ng mL‾1 with  statistically  significant  data  (p<0.05). The mean serum calcium levels in sub-clinical hypothyroid patients was 8.95+0.33 mg dL‾1 and in clinical hypothyroid was 8.14+0.11 mg dL‾1 with statistically significant data (p<0.05). In our study, there was a high proportion of vitamin D deficiency and hypocalcemia among patients with hypothyroidism. This indicates that screening may be needed to diagnose vitamin D deficiency and hypocalcemia in patient with hypothyroidism.

How to cite this article:

J.P. Vinay and C.N. Tejaswi . Clinical Profile of Hypothyroid Adults in Reproductive Age Group and Its Correlation with Serum Vitamin D and Calcium Levels at a Tertiary Care Hospital.
DOI: https://doi.org/10.36478/10.59218/makrjms.2022.34.37
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2022.34.37