Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Neonatal sepsis remains a significant contributor to illness and death in our nation. newborn sepsis accounts for approximately 30‐50% of all newborn mortality in underdeveloped nations. Although it is a serious disorder, it can be treated if detected early. Regrettably, the initial indications and symptoms are frequently vague and can be easily mistaken for those caused by non‐infectious factors. The research was carried out in the Pathology Department of a tertiary care hospital in Haldia. All the newborns who were believed to have sepsis or had a maternal history of infection were included in the study. The sepsis investigation involved performing full blood counts, measuring C‐reactive protein (CRP) and conducting blood culture tests to determine antibiotic sensitivity. A full blood count, including platelet count, total white blood cell count (WBC) and total neutrophil count (TNC). Absolute neutrophil counts (ANC) were determined based on the measured values. The standard values used were the reference values of the newborn hematological parameters from the study conducted by Manroe. Blood samples were taken prior to starting antibiotic treatment. The pathologist analyzed the peripheral smear data without knowing the infection status of the newborn. Analyzed were a total of 150 newborns with probable sepsis. Among 150 instances that were clinically suspected, 60 newborns were confirmed to have sepsis with blood culture, whereas 90 neonates were considered to likely have sepsis. An important discovery was the variation in the gender distribution of both groups. In the group of individuals suspected to have sepsis, 50% were male (n = 45) and 50% were female (n = 45). Among the babies in the confirmed septic group, 60% were male (36/60) and 40% were female (24/60). The percentage of premature infants in the group with probable sepsis was 60% (54 out of 90), while the group with confirmed sepsis included 70% (42 out of 60) of preterm neonates. The youngest was born after 25 weeks of pregnancy while the oldest was born after 41 weeks of pregnancy. The weight at birth varied from 730 grams to 4250 grams. Conclusion: The Hematologic profile that we examined is a straightforward, fast and cost‐effective approach in the early detection of newborn sepsis. However, its ability to accurately detect neonatal sepsis is not sufficient. To prevent factors that increase the risk of neonatal septicemia, such as premature birth and low birth weight, it is important to use aseptic procedures in delivery rooms and wards. Implementing a logical approach to antibiotic usage and following appropriate guidelines for the use of antimicrobial drugs would help decrease the emergence of resistance, which is becoming a worldwide concern. Thus, it is unable to offer guidance for judgments on antibiotic treatment.
How to cite this article:
Rohini Srivastava. A study on Role of the Hematological Investigation in Early Diagnosis of Neonatal Sepsis at Hospital in West Bengal.
DOI: https://doi.org/10.36478/10.59218/makrjms.2021.107.111
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2021.107.111