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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Study of Endothelial Cell Count Changes After Penetrating Keratoplasty (PK) vs Descemet’s Striping Endothelial Keratoplasty (DSEK)

Praful J. Chaudhary, Sanket Deshmukh, Amrut A. Swami and Kalyani P. Chaudhary
Page: 919-923 | Received 02 Aug 2023, Published online: 17 Aug 2023

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https://doi.org/10.36478/10.59218\makrjms.2023.919.923

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Abstract

Because corneal endothelial cells do not significantly multiply to allow endothelium regeneration, diseases of the corneal endothelium must be treated by transplanting corneal endothelial cells. Penetrating keratoplasty (PK), Descemet membrane endothelial keratoplasty (DMEK) and descemet stripping automated endothelial keratoplasty (DSAEK) are the most popular options for corneal transplants out of the several surgical techniques that have been offered. Endothelial keratoplasty or selective tissue transplantation have become more popular surgical treatments for endothelial disease than full thickness penetrating keratoplasty (PK). In place of penetrating keratoplasty (PK), descemet stripping automated endothelial keratoplasty (DSAEK) is now frequently used to address endothelial dysfunction. The objective of the current study was to assess the effects of PK and DSAEK in the treatment of corneal endothelial disease in terms of graft survival, endothelial cell loss and vision improvement. The current study was out to evaluate the effects of PK and DSAEK on graft survival, endothelial cell loss and visual improvement in the treatment of corneal endothelial disease. The difference between group A (PK) and group B (DSEK) in terms of mean corneal endothelial cell density (MCD) was only determined to be statistically significant after one year (p = 0.03). Before, there was no difference between the two group’s findings. Pachymetry results between the two groups did not reveal any statistically significant variation. Between the two groups, there was also no statistically significant difference in best corrected visual acuity (BCVA). According to the findings of the current investigation, DSAEK considerably improves mean corneal endothelial cell density (MCD) compared to PK. Therefore, in terms of the endothelial cell density result for corneal endothelial dysfunction, DSAEK may be a better surgical therapy option than PK.

How to cite this article:

Praful J. Chaudhary, Sanket Deshmukh, Amrut A. Swami and Kalyani P. Chaudhary. Study of Endothelial Cell Count Changes After Penetrating Keratoplasty (PK) vs Descemet’s Striping Endothelial Keratoplasty (DSEK).
DOI: https://doi.org/10.36478/10.59218\makrjms.2023.919.923
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218\makrjms.2023.919.923