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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Antimicrobial Sensitivity Pattern of Pseudomonas Aeruginosa in Healthcare‐Associated Infections: Hospital‐Based Study

Sumana Moitra, Santanu Hazra, Shampa Das, Amit Kumar Majumdar, Prabir Kumar Ghosh and Arpita Paul Dutta
Page: 63-68 | Received 20 Aug 2024, Published online: 12 Dec 2024

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https://doi.org/10.36478/10.36478/makrjms.2025.1.63.68

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Abstract

Pseudomonas aeruginosa, especially a multi drug‐resistant strain is an important pathogen responsible for the healthcare‐associated infection. Multi drug‐resistant Pseudomonas aeruginosa is increasingly encountered in healthcare settings, leaving clinicians with limited effective anti pseudo monal drugs for treatment. Thus, it presents a serious therapeutic challenge associated with increased morbidity and mortality. Identification of multi drug‐resistant strains and their antimicrobial sensitivity pattern is essential to develop proper antibiotic policy and effective antimicrobial stewardship program. This study aimed to determine antibiotic sensitivity profiles with the minimum inhibitory concentration of commonly used anti pseudo monal antibiotics against Pseudomonas aeruginosa associated with healthcare‐associated infections in a tertiary care hospital. One hundred and sixty consecutive, non‐repeat isolates of Pseudomonas aeruginosa were collected from various clinical samples. Susceptibility studies were performed, using E‐strips and minimum inhibitory concentrations of ceftazidime, cefepime, piperacillin/tazobactam, imipenem, meropenem, amikacin, gentamicin and colistin were tested and interpreted as per clinical laboratory standard institute guidelines. The only antibiotic with 100% susceptibility rates were colistin. The rate of susceptibility pattern was Imipenem 59.38%, Meropenem 55%, Piperacillin/Tazobactam 50.63%, Cefepime 36.25%, Ceftazidime 34.38%, Amikacin 38.13% and Gentamicin 20%. The results highlight the challenge of optimizing empirical antimicrobial therapy for Pseudomonas aeruginosa infections. It will be useful for clinicians to treat patients effectively, thus saving the cost and duration of patient care. It will also help the Infection Control Team in the selection of proper anti pseudo monal antibiotic policy and set an effective antimicrobial stewardship program.

How to cite this article:

Sumana Moitra, Santanu Hazra, Shampa Das, Amit Kumar Majumdar, Prabir Kumar Ghosh and Arpita Paul Dutta. Antimicrobial Sensitivity Pattern of Pseudomonas Aeruginosa in Healthcare‐Associated Infections: Hospital‐Based Study.
DOI: https://doi.org/10.36478/10.36478/makrjms.2025.1.63.68
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2025.1.63.68