Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Unmasking the Prevalence of Subclinical Hypothyroidism in Gallbladder Stone Patients: Prospective Study from a Tertiary Care Institute
Yogesh K. Swami, Nikunj D. Bhesaniya, Sameer H. Marediya and Ramkrishna Darji
Page: 633-636 | Received 10 Aug 2024, Published online: 17 Sep 2024
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Abstract
Gallstone disease is increasingly prevalent in India, particularly among South Asians. Studies suggest a possible link between hypothyroidism and gallstone formation due to factors like impaired bile flow and altered cholesterol metabolism. Despite a high incidence of gallstones in regions like Gujarat, the relationship between undiagnosed hypothyroidism and gallstone disease is not well explored. This study aims to investigate the prevalence of subclinical hypothyroidism in patients with gallstones and its potential role in gallstone formation. A prospective, hospital‐based, cross‐sectional study was conducted in a tertiary care teaching institute over a year, involving 160 patients diagnosed with gallstone disease. Detailed clinical histories, physical examinations and thyroid function tests (T3, T4, TSH) were performed. Patients were categorized into three groups: euthyroid, subclinical hypothyroid and hypothyroid. Exclusion criteria included prior thyroid surgery, diabetes mellitus, renal stones and pregnancy. Statistical analysis, including chi‐square and ANOVA tests, was used to assess the correlation between thyroid dysfunction and gallstone disease. Of the 160 patients, 38 (23.75%) had hypothyroidism, including 32 with subclinical hypothyroidism and 6 with overt hypothyroidism. Hypothyroidism was more prevalent in females (32.25%) than males (19.35%). Symptoms of biliary colic, fatty dyspepsia and right hypochondrial pain were common. The study highlights a significant association between hypothyroidism, particularly subclinical hypothyroidism and gallstone disease. Screening for thyroid dysfunction in patients with cholelithiasis could improve disease management and prevention.
How to cite this article:
Yogesh K. Swami, Nikunj D. Bhesaniya, Sameer H. Marediya and Ramkrishna Darji. Unmasking the Prevalence of Subclinical Hypothyroidism in Gallbladder Stone Patients: Prospective Study from a Tertiary Care Institute.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.9.633.636
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.9.633.636