Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Research has shown elevated HbA1c levels in anemic individuals, even though the lifespan of their erythrocytes is reduced. Lower Vitamin D levels have been suggested as an independent risk factor for type 2 diabetes mellitus (T2DM), often associated with elevated HbA1c. This study aims to evaluate and compare the levels of HbA1c, hemoglobin (Hb) and Vitamin D in non‐diabetic anemic individuals with those in healthy, age‐and sex‐matched control subjects. A case‐control study was designed, including 78 patients with anemia as cases and 80 healthy individuals as controls. Patients with diabetes, hemolytic anemia, parasitic infections, chronic alcohol consumption, or kidney disease were excluded. Routine blood tests, including fasting and postprandial glucose levels, along with HbA1c, Hb and Vitamin D concentrations, were measured in all participants. Vitamin D was assessed via ELISA, while fasting and postprandial glucose were measured using the GOD‐POD method. Hemoglobin concentration was determined by Drabkin’s method and HbA1c was measured using immunoturbidimetry. In patients with iron deficiency anemia (IDA), the average HbA1c level was significantly higher than the control group. There were no significant differences in fasting and postprandial blood sugar levels between the groups. A negative correlation was found between Vitamin D and HbA1c in both male and female subjects and between HbA1c and hemoglobin levels. A positive correlation was also observed between Vitamin D and hemoglobin concentrations. HbA1c is influenced by factors beyond blood glucose levels, particularly iron deficiency. It is important to rule out iron deficiency anemia before making clinical decisions based on HbA1c values.
How to cite this article:
Karan Chaudhari, Hemali Jha, Milav Bhavsar and Shinky Mehta. Assessment of Vitamin D and Glycated Hemoglobin in Non‐Diabetic Anemic Patients: A Clinical Study.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.9.628.632
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.9.628.632