Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Neurocognitive Function and Quality of Life Assessment in Patients Receiving Whole Brain Radiotherapy with Adjuvant Temozolamide and whole Brain Radiotherapy Alone: A Prospective Comparative Study
K.C. Jyothish and T.N. Vijayasree
Page: 538-543 | Received 15 Jul 2024, Published online: 26 Aug 2024
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Abstract
Metastases is defined as the spread of the tumour from primary site to a distant site. Brain is the most common site of Metastases and Whole Brain radiotherapy is the mainstay of treatment in these patients. To assess the Neurocognitive function and Quality of Life in patients with brain metastasis receiving Whole Brain Radiotherapy with concurrent Temozolamide, This Double arm prospective study was conducted in Department Of Radiation Oncology, Rajiv Gandhi Government General Hospital, Madras Medical College, Chennai From February‐2018 till July 2019. The most common carcinoma in the control arm was Ca Breast. Histopathologically the most common tumor type is Adenocarcinoma in the control arm and least common was the melanoma. Similarly in case of treatment arm the most common subtype is the Adenocarcinoma and the least common type were the poorly differentiated carciniomas. In both the arms patients had multiple sites of involvement followed by Right Parietel region. Brain metastases symptom were present before the beginning of WBRT in about 55% and absent in 45% of patient in both arms combined. The time period between the onset of decline in cognition is about one month earlier in the control arm than in the study arm. The range of decline is also very rapid in the control arm than in the study arm. the decline in executive function in the treatment arm was late when compared to control arm although there is no significant p‐value. there is statistically significant preservation of neurocognitive function in the motor skill assessment of non dominant hand and also in the visual motor scanning domain. There was also increase in overall survival of 3 months. Though all the other domains showed significant preservation of NCF but these were not statistically significant.
How to cite this article:
K.C. Jyothish and T.N. Vijayasree. Neurocognitive Function and Quality of Life Assessment in Patients Receiving Whole Brain Radiotherapy with Adjuvant Temozolamide and whole Brain Radiotherapy Alone: A Prospective Comparative Study.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.9.538.543
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.9.538.543