Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
Stroke is one of the major causes of morbidity and is the fifth important cause of mortality in the United States. The thyroid hormone level plays as an independent contributing factor for severity and functional outcome in patients of stroke. This study will help in understanding the correlation between the thyroid hormone levels and stroke outcome, which will have a greater impact in reducing morbidity and mortality in stroke patients. Our aim was to study the correlation between baseline thyroid function profile at the time of admission and on follow up days during hospital stay, with the outcome of ischemic stroke in form of functional disabilities and mortality in acute ischemic stroke. This was a longitudinal cohort study, conducted from June 2018‐May 2020 at the Department of Medicine, SCB Medical College, Cuttack.100 patients were enrolled with diagnosis of ischemic stroke and thyroid functions were measured at the time of admission, in hospitalisation and on follow up. Functional outcome using Modified rankin scale(MRS) were calculated. Correlation between thyroid status and stroke outcome in terms of functional disabilities were studied with the use of Study specific risk ratios. Low T3 levels were found in 55 number of patients in our study populations. Low T3 syndrome was associated with poor modified Rankin scale scores at 7day,1 and 3 months (odds ratio [OR] 0.023), 95% confidence interval [CI] 0.003‐0.177, P=.00 and OR 0.041, 95% CI 0.014‐0.177, P=.00 and OR 0.081,[CI] 0.031‐0.214,P=0.00, respectively). Poor outcome measured through MRS, was found in acute ischemic stroke patients having low T3 levels. This complex association needs a prospective and interventional study keeping in mind the role of correction of thyroid profile in acute ischemic stroke to improve the mortality and functional outcome.
How to cite this article:
Nirmal Chandra Sahu, Rukmani Jena, Abhishek Patro, Arvind Ranjan Mickey and Saroj Kumar Tripathy. Thyroid Profile In Patients Admitted With Ischemic Stroke: A Longitudinal Hospital Based Study.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.9.505.510
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.9.505.510