Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Surgical Sepsis is a life‐threatening complication that can lead to organ failure and death. Ulinastatin is a broad‐spectrum serine protease inhibitor with anti‐inflammatory and immunomodulatory properties. It has been shown to be effective in reducing mortality in patients with severe sepsis. The objective of this study is to evaluate the efficiency of Ulinastatin in improving clinical outcomes in patients with Surgical Sepsis. A retrospective study was conducted on 200 patients diagnosed with surgical sepsis. The patients were divided into two groups: a treatment group (N=100) who received Ulinastatin in addition to standard therapy and a control group (N=100) who received standard therapy alone. The primary outcome measure was the rate of mortality. Secondary outcome measures included the length of hospital stay, the incidence of organ failure, and the need for mechanical ventilation. We also changed the antibiotic class as per culture reports. The mortality rate was significantly lower in the treatment group (8%) compared to the control group (20%) (P=0.03). The treatment group also had a shorter length of hospital stay (12 days vs. 16 days, P=0.02) and a lower incidence of organ failure (12% vs. 24%, P=0.04). it was also noticed that the amount and number of days for which the antibiotic was given, was significantly reduced. There was no significant difference in the need for mechanical ventilation between the two groups. Ulinastatin appears to be a safe and effective treatment for Surgical Sepsis. It significantly reduces mortality, shortens hospital stay, and reduces the incidence of organ failure. Further research is needed to confirm these findings and explore the optimal dosing and timing of Ulinastatin administration in Surgical Sepsis patients.
How to cite this article:
Meghraj J. Chawada, Pranav Adhyapak, Gangadhar L. Anmod and Sudhir Deshmukh. The Efficacy of Ulinastatin in Surgical Sepsis at Tertiary Care Institute.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.9.445.450
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.9.445.450