Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Lower respiratory tract infections (LRTI) accounts for approximately 10% of world wide burden of morbidity and mortality. Discrimination between fungal colonization and infection is not easy and antifungal treatment is initiated empirically which is associated with an increase in adverse events and costs together with inappropriate therapy and increased mortality as treatment is delayed. To evaluate clinical, immunological, microbiological and radiological features of Aspergillus infection in patients with LRTI. A cross‐sectional study design including 100 Patients of age >15 years with LRTI in which Aspergillus infection was suspected like bronchial asthma ,ABPA, Aspergilloma, Immunocompromised host etc .were subjected to investigations like Chest X‐Ray and CECT Thorax , Sputum for fungal hyphae, Serum and BAL Galactomannan assay , IgG specific for Aspergillus and data was analysed using trial version of SPSS 16. The study showed that Serum and BAL galactomannan assay was positive in 25% of patients with LRTI. Sputum Aspergillus, Serum Galactomanan assay and IgG specific for Aspergillus were positive in 55%, 77% and 100% of patients respectively with radiological shadows suggestive of aspergilloma. Serum AEC>1000/mm3 and Total S.Ig E>100 IU/ml in 28% of patient. IgG specific for Aspergillus >8 U/ml was positive in 22% of patients. We therefore, conclude that S.IgG specific for Aspergillus is the most sensitive tool for Aspergiloma followed by serum Galactomannan assay, sputum for Aspergillus. So in highly Aspergillus infection suspected patients of LRTI, sending IgG specific for Aspergillus would save time and help in initiating therapy on time thereby decreasing mortality.
How to cite this article:
Bhuvaneshvari Prasad Verma and Devendra Pratap Yadav. Clinico‐Microbiological Profile of Lower Respiratory Tract Infections with Special Reference to Aspergillus Species.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.9.419.423
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.9.419.423