files/journal/2022-09-03_18-51-40-000000_599.png

Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
About US
Editors
Issues
Pages
Indexed in
115
Views
13
Downloads

Cross‐Sectional Study on the Prevalence of Hypothyroidism in Patients with Non‐Alcoholic Fatty Liver Disease (NAFLD)

Uday Bhan, Rajesh Kumar Gautam, Sanjeev Kumar Pandey, Brijesh Kumar, Mukesh Rana, Ashif Akhtar, Pooja Shukla, Praveen Prasad and Manoj Kumar Yadav
Page: 413-418 | Received 15 Jul 2024, Published online: 22 Aug 2024

Download Citation
https://doi.org/10.36478/10.36478/makrjms.2024.9.413.418

Full Text Reference XML File PDF File

Abstract

Non‐alcoholic fatty Liver Disease (NAFLD) is increasingly prevalent in India and is closely linked with metabolic disorders such as obesity and metabolic syndrome. Hypothyroidism is a common endocrine disorder that may exacerbate metabolic dysfunctions associated with NAFLD. This study aims to assess the prevalence of hypothyroidism in NAFLD patients and identify significant predictors of thyroid dysfunction within this population. A cross‐sectional study was conducted on 246 NAFLD patients in Eastern up at Mahamaya Rajkiya Allopathic Medical College, Saddarpur, Tanda, Ambedkar Nagar UP. Demographic, clinical and metabolic data were collected, and thyroid function was assessed using serum TSH, fT4 and fT3 levels. Logistic regression analysis was performed to identify predictors of hypothyroidism. Hypothyroidism was present in 34.1% of NAFLD patients, with 19.9% having subclinical hypothyroidism and 14.2% overt hypothyroidism. BMI and the presence of metabolic syndrome were significant predictors of hypothyroidism, with odds ratios of 1.10 (95% CI: 1.02‐1.18, p=0.014) and 1.65 (95% CI: 1.05‐2.59, p=0.031), respectively. Thyroid function tests showed significantly higher TSH levels and lower fT4 and fT3 levels in hypothyroid patients (p<0.001 for all). The study demonstrates a high prevalence of hypothyroidism among NAFLD patients in Eastern up, with BMI and metabolic syndrome being significant predictors. Routine screening for thyroid dysfunction in NAFLD patients, particularly those with higher BMI and metabolic syndrome, is recommended to improve management and outcomes.

How to cite this article:

Uday Bhan, Rajesh Kumar Gautam, Sanjeev Kumar Pandey, Brijesh Kumar, Mukesh Rana, Ashif Akhtar, Pooja Shukla, Praveen Prasad and Manoj Kumar Yadav. Cross‐Sectional Study on the Prevalence of Hypothyroidism in Patients with Non‐Alcoholic Fatty Liver Disease (NAFLD).
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.9.413.418
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.9.413.418