Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in premenopausal women, often associated with metabolic abnormalities such as insulin resistance and obesity. Nonalcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome, has been increasingly linked to PCOS, with potential implications for long‐term liver health. This study aimed to investigate the prevalence of NAFLD in women with PCOS compared to healthy controls and to evaluate the correlation between NAFLD severity and various clinical parameters using the NAFLD Fibrosis Score. A case‐control study was conducted at Raichur Institute of Medical Sciences from December 2022 to May 2024, including 100 women diagnosed with PCOS based on Rotterdam criteria and 100 age‐matched healthy controls. NAFLD was diagnosed using abdominal ultrasonography and the NAFLD Fibrosis Score, which incorporates age, BMI, hyperglycemia, platelet count, serum albumin and the AST/ALT ratio. Hematological and biochemical tests were performed to assess liver function, glucose metabolism and other relevant parameters. Statistical analysis was conducted using SPSS 22 and Epi‐info 7.2.1 software, with p‐values<0.05 considered significant. NAFLD was present in 24% of the PCOS group, compared to none in the control group (p<0.001). The PCOS group exhibited significantly higher fasting blood sugar, postprandial blood sugar, ALT and AST levels. Furthermore, 26% of the PCOS group had a NAFLD Fibrosis Score greater than 0.0, indicating a higher likelihood of advanced fibrosis, with 30% of the PCOS group in the F2‐F4 fibrosis categories on Fibro Scan, compared to none in the control group (p<0.001). NAFLD is significantly more prevalent in women with PCOS, with a notable proportion exhibiting advanced liver fibrosis. The correlation between NAFLD severity and clinical parameters such as BMI and insulin resistance underscores the need for early screening and intervention in this population to prevent progression to severe liver disease.
How to cite this article:
Vandana and G. Anil Kumar. Study Of Occurrence of Non‐alcoholic Fatty Liver Disease (NAFLD) In Polycystic Ovarian Syndrome (PCOS).
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.9.304.309
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.9.304.309