Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Total intravenous anesthesia (TIVA) is widely used in various surgical settings due to its ability to provide controlled anesthesia with minimal postoperative complications. Clonidine and dexmedetomidine, both a2‐adrenergic agonists, are commonly used as adjuvants in TIVA. This study aims to compare the effects of clonidine and dexmedetomidine as adjuvants in TIVA for short‐duration surgeries. A prospective, randomized, double‐blind study was conducted with 55 adult patients scheduled for elective short‐duration surgeries under TIVA. Patients were randomly assigned to receive either clonidine (Group C, n=27) or dexmedetomidine (Group D, n=28) as adjuvants. The primary outcomes measured were intraoperative hemodynamic parameters (heart rate and mean arterial pressure), recovery times (time to extubation and time to orientation) and postoperative pain scores (Visual Analog Scale at 1, 2, and 6 hours postoperatively). Secondary outcomes included the incidence of adverse effects such as bradycardia, hypotension and postoperative nausea and vomiting, as well as sedation levels (Ramsay Sedation Scale). Dexmedetomidine was associated with lower intraoperative heart rates and mean arterial pressure compared to clonidine. Recovery times were shorter in the dexmedetomidine group, with mean time to extubation and orientation being significantly less than in the clonidine group. Postoperative pain scores were lower in the dexmedetomidine group at all time points. While the incidence of bradycardia and hypotension was slightly higher in the dexmedetomidine group, these effects were manageable. Sedation levels were higher in the dexmedetomidine group, indicating deeper sedation. Dexmedetomidine offers superior hemodynamic stability, faster recovery, better postoperative analgesia, and deeper sedation compared to clonidine in TIVA for short‐duration surgeries. However, the increased risk of bradycardia and hypotension requires careful monitoring. Dexmedetomidine may be preferred as an adjuvant in TIVA for short‐duration surgeries, particularly where rapid recovery and effective postoperative pain management are critical.
How to cite this article:
. Comparative Study of Clonidine and Dexmedetomidine as Adjuvants in Total Intravenous Anesthesia for Short‐Duration Surgeries.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.9.177.182
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.9.177.182