Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Guillain‐Barré Syndrome (GBS) is an inflammatory polyradiculoneuropathy with varied clinical manifestation and often dismal prognosis if not promptly treated. Recommended treatment modalities [intravenous immunoglobulin (IVIG) and plasma exchange (PE)] are costly and the role of steroids is controversial. In this study, we reviewed the clinical and laboratory findings of consecutive patients with GBS (n=100) and explored factors associated with outcome. We also compared response to different modalities of treatment including steroids. Treatment with IVIG and plasma pharesis had better outcome than placebo. However there was no significant difference between the treatment outcomes of IVIG and PE and we found a non‐significant trend toward improvement with intravenous (IV) steroid. We observed 3% mortality and most common cause of death was respiratory failure. Increased age, early peak disability, autonomic dysfunction, bulbar weakness, and reduced compound muscle action potential (CMAP) delay in starting treatment, were associated with a poorer outcome. Group of patients treated with IVIG and plasma pheresis showed more improvement than the IV methylprednisolone group.
How to cite this article:
Shivakumar K. Masaraddi, Shivajirao Brid and Rohan Desai. Guillain‐Barré Syndrome: Clinical Profile of 100 Patients Admitted at Tertiary Care Centre in South India.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.9.154.159
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.9.154.159